本研究评估了姜黄素和多西他赛（DTX）联合治疗头颈部鳞状细胞癌（HNSCC）的可行性。动物实验表明，DTX在改善免疫抑制微环境方面存在一定限制。姜黄素治疗克服了这种抑制，减少了肿瘤进展。姜黄素协同DTX显示出显著更高的肿瘤负担减少效果，比单独治疗下调MDSCs，M2巨噬细胞，上调CD8+ T细胞，NK细胞，M1巨噬细胞。同时，肿瘤中CXCL1的分泌减少。相反，干扰素-γ和肿瘤坏死因子-α的分泌量增加。我们的研究为HNSCC提供了一种有前途的治疗策略。

This study evaluated the feasibility of curcumin and docetaxel (DTX) combination therapy for head and neck squamous cell carcinoma (HNSCC). Animal assay demonstrated DTX has certain limitations in improving immunosuppressive microenvironment. Treatment with curcumin overcame this inhibition and reduced tumor progression. Curcumin synergized DTX showed significantly greater reduction in tumor burden than either treatment alone via down-regulation of MDSCs, M2 macrophages and up-regulation of CD8+ T cells, NK cells, M1 macrophages. Meanwhile, the secretion of CXCL1 was decreased in tumor. Conversely, the secretion of interferon-γ and tumor necrosis factor-α were increased. Our study provided a promising therapeutic strategy for HNSCC.