肿瘤相关疲劳（CRF）是小儿肿瘤学中最常见和令人痛苦的症状之一。根据以往研究，体育活动干预被认为可以有效减少成人癌症患者的CRF。本系统综述的目的是调查体育活动干预是否可以减少接受癌症治疗的小儿患者的CRF。我们于2021年10月在PubMed和Sport-Discus中进行了系统文献检索，以识别研究物理活动对21岁及以下小儿癌症患者CRF效果的干预研究。使用JBI关键评价工具评估了它们的方法论质量。本综述共纳入了20项研究（七个随机对照、六个准实验和七个单臂干预试验）。九项研究在组间或组内比较中报告了物理活动干预对CRF的显著正面影响。11项试验报告了CRF没有显著变化。小儿肿瘤学中的体育活动作为治疗干预可能有潜力减少接受癌症治疗的儿童癌症患者的CRF。需要进一步进行具有大样本量的高质量研究，以验证这些结果并评估物理活动干预的剂量和响应之间的相互关系。

Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in paediatric oncology. Based on previous studies, physical activity interventions are considered to be effective in reducing CRF in adult cancer patients.The aim of this systematic review is to investigate whether physical activity interventions can reduce CRF in paediatric patients undergoing cancer treatment.A systematic literature search was conducted in PubMed and Sport-Discus in October 2021 to identify intervention studies examining the effects of physical activity on CRF in cancer patients ≤ 21 years of age. Their methodological quality was assessed using the JBI Critical Appraisal Tool.A total of 20 studies (seven randomized-controlled, six quasi-experimental and seven single-arm intervention trials) were included in the review. Nine studies reported significant positive effects of physical activity interventions on CRF in group comparison or within groups. Eleven trials reported no significant changes in CRF.Physical activity as a therapeutic intervention in paediatric oncology may have the potential to reduce CRF in childhood cancer patients undergoing cancer treatment. Further high-quality studies with large samples are needed to verify these results and to assess the interdependence of dose and response of physical activity interventions.