研究动态
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近年来,铼基材料在诊断和肿瘤治疗应用中的最新发展。

Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy.

发表日期:2023 Mar 17
作者: Qingwen Qi, Qian Wang, Yuhao Li, Dionisio Zaldivar Silva, Maria Eliana Lanio Ruiz, Ruizhuo Ouyang, Baolin Liu, Yuqing Miao
来源: PHYSICAL THERAPY & REHABILITATION JOURNAL

摘要:

铼(Re)因其独特的物理和化学性质而广泛应用于癌症的诊断和治疗中。Re的外层壳层中有更多的化合价电子,使其能够存在于各种氧化状态,并与许多不同的配体形成不同的几何构型。通过改变Re的配体,可以调节其复合物的发光性能、亲脂性和细胞毒性。本文主要综述了放射性核素188Re在放射治疗中的发展,Re的一些创新应用以及癌症治疗中使用的不同治疗方法和成像技术。此外,还讨论了Re的当前应用和未来的挑战和机遇。
Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands. The luminescence properties, lipophilicity, and cytotoxicity of complexes can be adjusted by changing the ligand of Re. This article mainly reviews the development of radionuclide 188Re in radiotherapy and some innovative applications of Re as well as the different therapeutic approaches and imaging techniques used in cancer therapy. In addition, the current application and future challenges and opportunities of Re are also discussed.