研究动态
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儿童癌症幸存者中的维生素D缺乏症:泰国南部的结果。

Vitamin D Deficiency in Childhood Cancer Survivors: Results from Southern Thailand.

发表日期:2023 Mar 08
作者: Sirinthip Kittivisuit, Pornpun Sripornsawan, Natsaruth Songthawee, Shevachut Chavananon, Umaporn Yam-Ubon, Edward B McNeil, Somchit Jaruratanasirikul, Thirachit Chotsampancharoen
来源: TROPICAL MEDICINE & INTERNATIONAL HEALTH

摘要:

儿童癌症幸存者(CCS)的维生素D缺乏情况存在有限的信息,尤其是在热带国家。本研究旨在确定CCS的维生素D缺乏的患病率和风险因素。该研究在泰国宋卡普王子大学CCS长期随访诊所进行,纳入了2021年1月至2022年3月期间随访的所有CCS。收集了人口统计学数据、饮食乳制品摄入量、户外活动的平均每周时间、总25-羟基维生素D[25(OH)D]水平、甲状旁腺激素水平和血液化学指标。总共纳入了206名年龄在随访时平均为10.8±4.7岁的CCS。维生素D缺乏的患病率为35.9%。女性(比值比(OR):2.11,95% CI:1.08-4.13)、肥胖(OR:2.01,95% CI:1.00-4.04)、缺乏户外活动(OR:4.14,95% CI:2.08-8.21)和较低的饮食乳制品摄入量(OR:0.59,95% CI:0.44-0.80)是维生素D缺乏的独立风险因素。CCS普遍存在维生素D缺乏症,与女性、肥胖、缺乏户外活动和较低的饮食乳制品摄入量有关。应在长期护理中建立定期的25(OH)D筛查,以确定那些需要维生素D补充的患者。
There is limited information on vitamin D deficiency among childhood cancer survivors (CSS), especially in tropical countries. The aims of this study are to determine the prevalence and risk factors for vitamin D deficiency in CCSs. This study was conducted at the long-term follow-up clinic for CCSs at Prince of Songkla University, Songkhla, Thailand. All CCSs who were followed up between January 2021 and March 2022 were enrolled. Demographic data, dietary dairy intake, average weekly duration of outdoor activities, total 25-hydroxyvitamin D [25(OH)D] levels, parathyroid hormone levels, and blood chemistry were collected. A total of 206 CCSs with a mean age at follow-up of 10.8 ± 4.7 years were included. The prevalence of vitamin D deficiency was 35.9%. Female gender (odds ratio (OR): 2.11, 95% CI: 1.08-4.13), obesity (OR: 2.01, 95% CI: 1.00-4.04), lack of outdoor activities (OR: 4.14, 95% CI: 2.08-8.21), and lower dietary dairy intake (OR: 0.59, 95% CI: 0.44-0.80) were independent risk factors for vitamin D deficiency. Vitamin D deficiency was common in CCSs and associated with female gender, obesity, lack of outdoor activities, and lower dietary dairy intake. Regular 25(OH)D screening should be established in long-term care to identify those who require vitamin D supplements.