癌症是全球主要的公共卫生问题之一。尽管癌症治疗有所进步，但由于治疗的低特异性和多重药物抗性机制的发展，它仍然是一项挑战。为了克服这些缺点，已经研究了几种药物输送纳米系统，其中包括磁性纳米颗粒（MNP），尤其是超顺磁铁氧化铁纳米颗粒（SPION），已被用于治疗癌症。MNP能够通过外加磁场引导到肿瘤微环境。此外，在交变磁场（AMF）存在的情况下，这种纳米载体可以通过尼尔（Néel）和布朗（Brown）弛豫将电磁能转化为热能（高于42°C），使其适用于高温疗法。然而，MNP的化学和物理稳定性较低，因此需要涂层。因此，脂质基纳米颗粒，尤其是脂质体，已被用于封装MNP，以提高其稳定性并使其可用于癌症治疗。本综述重点介绍了使MNP适用于癌症治疗的主要特点以及使用混合磁性脂质基纳米颗粒进行该目的的纳米医学领域中的最新研究。

Cancer is one of the major public health problems worldwide. Despite the advances in cancer therapy, it remains a challenge due to the low specificity of treatment and the development of multidrug resistance mechanisms. To overcome these drawbacks, several drug delivery nanosystems have been investigated, among them, magnetic nanoparticles (MNP), especially superparamagnetic iron oxide nanoparticles (SPION), which have been applied for treating cancer. MNPs have the ability to be guided to the tumor microenvironment through an external applied magnetic field. Furthermore, in the presence of an alternating magnetic field (AMF) this nanocarrier can transform electromagnetic energy in heat (above 42 °C) through Néel and Brown relaxation, which makes it applicable for hyperthermia treatment. However, the low chemical and physical stability of MNPs makes their coating necessary. Thus, lipid-based nanoparticles, especially liposomes, have been used to encapsulate MNPs to improve their stability and enable their use as a cancer treatment. This review addresses the main features that make MNPs applicable for treating cancer and the most recent research in the nanomedicine field using hybrid magnetic lipid-based nanoparticles for this purpose.