糖尿病性创口感染（DWI）是糖尿病最昂贵和最严重的并发症之一。高血糖状态会引起持续的炎症反应，导致免疫和生化功能障碍，从而推迟创口愈合过程和创口感染，最终导致长期住院和肢体截肢。目前，治疗DWI的可用疗法极其痛苦和昂贵。因此，开发和改进DWI特定疗法以在多个方面进行干预是必不可少的。槲皮素（QUE）具有出色的抗炎、抗氧化、抗微生物和创口愈合特性，这使得它成为管理糖尿病性创口的有前途的分子。在本研究中，研制了载荷QUE的聚乳酸/聚乙烯吡咯烷酮（PP）共电纺纤维。结果显示，双峰直径分布的接触角从120°/127°开始，在不到5秒钟的时间内降至0°，表明制备样品的亲水性质。在模拟创伤流体（SWF）中分析的QUE释放动力学表明，有强烈的初始爆发释放，随后是持续不断的QUE释放。此外，QUE载荷膜具有出色的抗生物膜和抗炎能力，并显著降低了分化的巨噬细胞中M1标记物肿瘤坏死因子（TNF）-α和IL-1β的基因表达。总之，结果表明，载荷QUE的制备垫可能成为有效治疗糖尿病性创口感染的有希望的药物输送系统。

Diabetic wound infections (DWI) represent one of the most costly and disruptive complications in diabetic mellitus. The hyperglycemic state induces a persistent inflammation with immunological and biochemical impairments that promotes delayed wound healing processes and wound infection that often results in extended hospitalization and limb amputations. Currently, the available therapeutic options for the management of DWI are excruciating and expensive. Hence, it is essential to develop and improve DWI-specific therapies able to intervene on multiple fronts. Quercetin (QUE) exhibits excellent anti-inflammatory, antioxidant, antimicrobial and wound healing properties, which makes it a promising molecule for the management of diabetic wounds. In the present study, Poly-lactic acid/poly(vinylpyrrolidone) (PP) co-electrospun fibers loaded with QUE were developed. The results demonstrated a bimodal diameter distribution with contact angle starting from 120°/127° and go to 0° in less than 5 s indicating the hydrophilic nature of fabricated samples. The release QUE kinetics, analyzed in simulated wound fluid (SWF), revealed a strong initial burst release, followed by a constant and continuous QUE release. Moreover, QUE-loaded membranes present excellent antibiofilm and anti-inflammatory capacity and significantly reduce the gene expression of M1 markers tumor necrosis factor (TNF)-α, and IL-1β in differentiated macrophages. In conclusion, the results suggested that the prepared mats loaded with QUE could be a hopeful drug-delivery system for the effective treatment of diabetic wound infections.