尽管近年来取得了一些进展，癌症仍然是全球最主要的杀手。已经开展了大量的研究，以发现新型和有效的抗癌药物。乳腺癌的复杂性是一项重大挑战，它与患者间的变异和肿瘤内部细胞的异质性相结合。革命性的药物传递有望提供解决这一挑战的办法。壳聚糖纳米粒子（CSNPs）有望成为革命性的传递系统，能够增强抗癌药物的活性并降低对正常细胞的负面影响。使用智能药物传递系统（SDDs）作为传递材料，以改善纳米粒子的生物活性并了解乳腺癌的复杂性，已经引起了极大的兴趣。有许多关于CSNPs的评论提出了各种观点，但它们还没有描述从细胞摄取到细胞死亡的癌症治疗系列。通过这个描述，我们将为设计SDDs的制备提供更完整的图片。这篇综述介绍了CSNPs作为SDDSs，利用其抗癌机制，增强癌症治疗的靶向和刺激响应。多模式壳聚糖SDDs作为靶向和刺激响应的药物输送将改善治疗效果。

Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.