结肠直肠癌有时被称为结肠癌或直肠癌，这取决于癌细胞开始形成的位置，它是男性和女性第二大癌症死亡原因。铂基[PtCl（8-O-喹啉酮）（二甲基亚砜）]（8-QO-Pt）化合物表现出有希望的抗癌活性。研究了三种不同的8-QO-Pt包被纳米结构脂质体（NLC）和核黄素（RFV）系统。在RFV的存在下，以肌酸酯为基质的NLC被超声波合成。RFV修饰的纳米粒子呈球形，平均粒径在144-175 nm之间。超过70%的包封效率的NLC / RFV的8-QO-Pt加载公式显示了持续的体外释放24h。在HT-29人结肠腺癌细胞系中评估了细胞毒性，细胞摄取和细胞凋亡。结果显示，相对于5.0 µM的8-QO-Pt自由化合物，NLC / RFV的8-QO-Pt加载公式表现出更高的细胞毒性。所有三个系统的细胞内嵌入程度不同。此外，血毒性分析显示配方的安全性（小于3.7％）。总之，我们的研究首次研究了RFV靶向NLC系统中的药物传递，并且结果对结肠癌治疗的化疗未来很有前途。

Colorectal cancer is occasionally called colon or rectal cancer, depending on where cancer begins to form, and is the second leading cause of cancer death among both men and women. The platinum-based [PtCl(8-O-quinolinate)(dmso)] (8-QO-Pt) compound has demonstrated encouraging anticancer activity. Three different systems of 8-QO-Pt-encapsulated nanostructured lipid carriers (NLCs) with riboflavin (RFV) were investigated. NLCs of myristyl myristate were synthesized by ultrasonication in the presence of RFV. RFV-decorated nanoparticles displayed a spherical shape and a narrow size dispersion in the range of 144-175 nm mean particle diameter. The 8-QO-Pt-loaded formulations of NLC/RFV with more than 70% encapsulation efficiency showed sustained in vitro release for 24 h. Cytotoxicity, cell uptake, and apoptosis were evaluated in the HT-29 human colorectal adenocarcinoma cell line. The results revealed that 8-QO-Pt-loaded formulations of NLC/RFV showed higher cytotoxicity than the free 8-QO-Pt compound at 5.0 µM. All three systems exhibited different levels of cellular internalization. Moreover, the hemotoxicity assay showed the safety profile of the formulations (less than 3.7%). Taken together, RFV-targeted NLC systems for drug delivery have been investigated for the first time in our study and the results are promising for the future of chemotherapy in colon cancer treatment.