肉桂醛含量的聚合物及其生物医学应用。
Cinnamaldehyde-Contained Polymers and Their Biomedical Applications.
发表日期:2023 Mar 18
作者:
Guangyan Zhang, Tianlong Li, Jia Liu, Xinran Wu, Hui Yi
来源:
Environmental Technology & Innovation
摘要:
肉桂醛是一种天然产物,可以从肉桂属多种植物中提取,展现出出色的生物活性,包括抗菌、抗真菌、抗炎和抗癌特性。为了克服肉桂醛的缺点(如水溶性差和对光敏感)或增强其优点(如高反应性和促进细胞反应性氧自由基产生),肉桂醛可以被载入或与聚合物结合以实现持续或可控释放,从而延长其生物活性的有效作用时间。此外,当肉桂醛与聚合物结合时,通过形成醛基与聚合物各种功能基团之间的刺激敏感连接,还能向聚合物引入环境响应性。这种环境响应性为肉桂醛结合聚合物在生物医学领域的应用提供了巨大潜力。本综述总结了制备含肉桂醛聚合物的策略,并回顾了它们在生物医学领域的应用。
Cinnamaldehyde, a natural product that can be extracted from a variety of plants of the genus Cinnamomum, exhibits excellent biological activities including antibacterial, antifungal, anti-inflammatory, and anticancer properties. To overcome the disadvantages (e.g., poor water solubility and sensitivity to light) or enhance the advantages (e.g., high reactivity and promoting cellular reactive oxygen species production) of cinnamaldehyde, cinnamaldehyde can be loaded into or conjugated with polymers for sustained or controlled release, thereby prolonging the effective action time of its biological activities. Moreover, when cinnamaldehyde is conjugated with a polymer, it can also introduce environmental responsiveness to the polymer through the form of stimuli-sensitive linkages between its aldehyde group and various functional groups of polymers. The environmental responsiveness provides the great potential of cinnamaldehyde-conjugated polymers for applications in the biomedical field. In this review, the strategies for preparing cinnamaldehyde-contained polymers are summarized and their biomedical applications are also reviewed.