背景：以前的队列研究在动物内脏摄入与抑郁症状之间的关联方面的研究有限，特别是在亚洲人口中。本研究旨在前瞻性研究一般中国成年人口中动物内脏摄入与抑郁症状风险之间的关联性。方法：本前瞻性队列研究共包括中国天津市居民7745名（57.6％男性）。在基线时没有心血管疾病、癌症和抑郁症状的参与者随访1.5至5年，随访中位数为3年。使用经过验证的自我管理的食物频率问卷评估动物内脏的摄入量，使用中文版Zung自评抑郁量表（SDS），并将截止得分设置为45来评估抑郁症状。使用Cox比例风险回归模型来估计动物内脏摄入与抑郁症状之间的关联。结果：在随访19074人年中，共1101人（630男性）出现抑郁症状。在对多种潜在混淆因素进行校正并将“几乎从不”作为对照组后，三分位动物内脏的多变量风险比（95％置信区间）分别为0.96（0.81，1.15）、1.04（0.87，1.24）和1.34（1.13，1.58）（趋势P<0.001）。结论：我们前瞻性研究的结果表明，动物内脏的摄入与抑郁症状呈正相关。

Background: Previous cohort studies on the association between animal offal intake and depressive symptoms are limited, especially in Asian populations. This study aimed to prospectively investigate the association between animal offal intake and the risk of depressive symptoms in a general Chinese adult population. Methods: This prospective cohort study included a total of 7745 (57.6% males) inhabitants living in Tianjin, China. Participants without a history of CVD, cancer, and depressive symptoms at the baseline were followed up for 1.5 to 5 years with a median of 3 years follow-up. Animal offal was assessed using a validated self-administered food frequency questionnaire. Depressive symptoms were evaluated using the Chinese version of the Zung Self-Rating Depression Scale (SDS) and the cutoff score was set at 45. Cox proportional hazards regression models were used to estimate the association between animal offal intake and depressive symptoms. Results: A total of 1101 (630 men) people developed depressive symptoms during 19 074 person-years of follow-up. After adjusting for several potential confounders and setting "almost never" as the control group, the multivariable hazard ratios (95% confidence intervals) of the depressive symptoms were 0.96 (0.81, 1.15) for tertile 1, 1.04 (0.87, 1.24) for tertile 2, and 1.34 (1.13, 1.58) for tertile 3, respectively (P for trend <0.001). Conclusion: The results from our prospective study demonstrated that the intake of animal offal is positively associated with depressive symptoms.