癌症转移，或在远处组织中发展次生肿瘤，在乳腺癌患者中导致绝大多数死亡。乳腺癌细胞具有明显的转移倾向，特别是肺、肝、骨和脑等不同器官，这些器官面临着独特的环境压力和多种组织驻留细胞，共同创造了一种强大的肿瘤生存和生长屏障。因此，成功的转移定植在很大程度上取决于癌细胞与目标器官内的宿主细胞之间的相互交流，这种关系塑造了肿瘤支持微环境的形成。在这里，我们讨论了乳腺癌中器官特异性转移的机制，着重介绍了转移细胞和次生器官中特定的微环境细胞之间错综复杂的相互作用以及两个区域的显着适应，这两方面共同支持癌症生长。更广泛地说，我们旨在为每个不同的转移部位提供微环境必备条件的框架，以实现成功的乳腺癌转移种植和生长。 版权所有©2023 Cold Spring Harbor Laboratory Press；保留所有权利。

Cancer metastasis, or the development of secondary tumors in distant tissues, accounts for the vast majority of fatalities in patients with breast cancer. Breast cancer cells show a striking proclivity to metastasize to distinct organs, specifically the lung, liver, bone, and brain, where they face unique environmental pressures and a wide variety of tissue-resident cells that together create a strong barrier for tumor survival and growth. As a consequence, successful metastatic colonization is critically dependent on reciprocal cross talk between cancer cells and host cells within the target organ, a relationship that shapes the formation of a tumor-supportive microenvironment. Here, we discuss the mechanisms governing organ-specific metastasis in breast cancer, focusing on the intricate interactions between metastatic cells and specific niche cells within a secondary organ, and the remarkable adaptations of both compartments that cooperatively support cancer growth. More broadly, we aim to provide a framework for the microenvironmental prerequisites within each distinct metastatic site for successful breast cancer metastatic seeding and outgrowth.Copyright © 2023 Cold Spring Harbor Laboratory Press; all rights reserved.