恶性脑肿瘤是中枢神经系统中最具威胁性的疾病之一，尽管不断更新的治疗方法，预后仍未得到改善。肿瘤治疗场（TTFields）是一种使用中频和低强度电场的癌症治疗新方法，可以促进新的治疗选择的开发。TTFields引起的一系列生物过程能够产生抗癌效果。最近的研究表明，TTFields可以改变癌症生物学中涉及的大分子和细胞器的生物电状态。TTFields引起的癌细胞蛋白质组学和转录组学的大规模改变与细胞生物学过程以及多个细胞器结构和活动相关。本文阐述了TTFields的机制和在恶性脑肿瘤特别是在胶质母细胞瘤（GBM）治疗中的最新进展。作为一种新型治疗策略，TTFields在许多临床试验中显示出有希望的结果，特别是在GBM方面，并且持续发展。越来越多的恶性脑肿瘤患者正在进行进行性的临床研究，表明基于TTFields的联合治疗可以改善治疗结果。© 2023 The Authors. Wiley Periodicals LLC出版的《Cancer Reports》。

Malignant brain tumors are among the most threatening diseases of the central nervous system, and despite increasingly updated treatments, the prognosis has not been improved. Tumor treating fields (TTFields) are an emerging approach in cancer treatment using intermediate-frequency and low-intensity electric field and can lead to the development of novel therapeutic options.A series of biological processes induced by TTFields to exert anti-cancer effects have been identified. Recent studies have shown that TTFields can alter the bioelectrical state of macromolecules and organelles involved in cancer biology. Massive alterations in cancer cell proteomics and transcriptomics caused by TTFields were related to cell biological processes as well as multiple organelle structures and activities. This review addresses the mechanisms of TTFields and recent advances in the application of TTFields therapy in malignant brain tumors, especially in glioblastoma (GBM).As a novel therapeutic strategy, TTFields have shown promising results in many clinical trials, especially in GBM, and continue to evolve. A growing number of patients with malignant brain tumors are being enrolled in ongoing clinical studies demonstrating that TTFields-based combination therapies can improve treatment outcomes.© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.