高迁移性AT结合蛋白2（HMGA2）是一种基因调节蛋白，与转移潜力和恶劣预后有关。研究表明，HMGA2在肺癌或胰腺癌等各种肿瘤中被过度表达。高侵袭性和高度侵略性的胶质母细胞瘤的结构让我们更加密切地研究肿瘤边缘区域中HMGA2的表达情况。我们比较了胶质母细胞瘤和正常脑组织中的HMGA2表达情况。此外，我们分析和比较了肿瘤的边缘和中心区域中的HMGA2表达情况。进行了HMGA表达与临床参数（如MGMT状态和生存率）之间的相关性检测。使用实时荧光定量PCR和免疫组织化学方法，分别对23名WHO 4级胶质母细胞瘤患者的样本进行了HMGA2表达分析，并与临床参数相关联。肿瘤中心和边缘区域分别进行了分析。两个正常脑组织标本用作对照。我们的结果证实，与健康脑组织相比，胶质母细胞瘤中HMGA2表达更高（qPCR，P = 0.013; IHC，P = 0.04）。此外，免疫组织化学方法显示，肿瘤边缘区域中HMGA2表达显著高于肿瘤中心区域（P = 0.012）。生存分析显示，在HMGA2在边缘区表达较高时，生存时间趋短。结果表明，在胶质母细胞瘤的边缘区域中存在HMGA2的过表达；因此，HMGA2表达群集似乎是异质性的，通过全面的手术切除重要的和具有侵略性的边缘细胞，有助于抑制肿瘤的侵袭性。

High-mobility group AT-hook protein 2 (HMGA2) is a gene regulatory protein that is correlated with metastatic potential and poor prognosis. It has been shown that HMGA2 is overexpressed in various tumors such as lung cancer or pancreatic cancer. The invasive character and highly aggressive structure of glioblastoma let us to investigate HMGA2 expression in the border zone of the tumor more closely. We compared HMGA2 expression between glioblastoma and normal brain tissue. In addition, we analyzed and compared HMGA2 expression in the border and center zones of tumors. Correlation tests between HMGA expression and clinical parameters such as MGMT-status and survival were performed.Samples from 23 patients with WHO grade 4 glioblastomas were analyzed for HMGA2 expression using quantitative real-time polymerase chain reaction (qPCR) and immunohistochemistry (IHC) and correlated with clinical parameters. The areas from the tumor center and border were analyzed separately. Two normal brain tissue specimens were used as the controls.Our results confirm that HMGA2 is higher expressed in glioblastoma compared to healthy brain tissue (qPCR, P=0.013; IHC, P=0.04). Moreover, immunohistochemistry revealed significantly higher HMGA2 expression in the border zone of the tumor than in the tumor center zone (P=0.012). Survival analysis revealed a tendency for shorter survival when HMGA2 was highly expressed in the border zone.The results reveal an overexpression of HMGA2 in the border zone of glioblastomas; thus, the expression cluster of HMGA2 seems to be heterogenous and thorough borough surgical resection of the vital and aggressive border cells might be important to inhibit the invasive character of the tumor.