钻石黑斑贫血（DBA）是一种遗传性骨髓衰竭综合症，相关特征包括严重贫血、先天畸形和增加患癌风险。染色质结合SATB1在患者和DBA细胞模型中的Megakaryocyte / Erythroid Progenitors（MEPs）中下调，导致MEP扩张减少。在此，我们证明SATB1表达对于随着MEP分化而伴随的重要红细胞因素HSP70和GATA1的上调是必需的。SATB1结合周围HSP70基因特定位点，促进诱导HSP70所需的染色质环，进而促进GATA1诱导。这表明，SATB1虽然在骨髓系炎症过程中逐渐下调，但在早期髓样祖细胞中仍然保持生物学功能。©作者（s）2023。由Oxford University Press出版。版权所有。有关权限，请发送电子邮件至：journals.permissions@oup.com。

Diamond Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome associated with severe anemia, congenital malformations and increased risk of developing cancer. The chromatin-binding SATB1 is downregulated in Megakaryocyte/Erythroid Progenitors (MEPs) in patients and cell models of DBA, leading to a reduction in MEP expansion. Here we demonstrate that SATB1 expression is required for the upregulation of the critical erythroid factors HSP70 and GATA1 that accompanies MEP differentiation. SATB1 binding to specific sites surrounding the HSP70 genes, promotes chromatin loops that are required for induction of HSP70, which in turn promotes GATA1 induction. This demonstrates that SATB1, although gradually downregulated during myelopoiesis, maintains a biological function in early myeloid progenitors.© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.