本研究旨在阐述神经肿瘤手术骨钻术后手术部位感染（SSI）的风险因素病因学，并调查它们对感染率的组合影响。包括2006年至2020年接受神经肿瘤骨钻术的患者。回顾医疗记录以确定术后≤3个月内切口感染的发生情况。可能的感染风险因素包括肿瘤病理学、位置、麻醉类型、指征、脑室入口、异物、放射治疗、腰穿、先前手术、先前颅内放疗、先前感染、贝伐单抗和医疗并发症（高血压、肥胖症、糖尿病、高脂血症、其他癌症、肝硬化）。实施逻辑回归以确定SSI的风险因素。使用卡方检验评估具有不同风险因素数量（如0、≥1、≥2、≥3、≥4）的患者是否相对于具有较少风险因素的患者增加SSI的风险。同时评估每个额外风险因素的相对增加。总共包括1209名患者。术后90天内有42名患者（3.5％）发生SSI。多元逻辑回归的重要风险因素包括贝伐单抗（OR 40.84; p＜0.001）、肝硬化（OR 14.20，p＝0.03）、异物（OR 4.06; P＜0.0001）、先前放射治疗（OR 2.20; p＝0.03）和先前手术（OR 1.92; p＝0.04）。在组合分析中的感染率如下：≥1个风险因素=5.9％（OR 2.74; p＝0.001），≥2％=6.7％（OR 2.28; p＝0.01），≥3％=19.0％（OR 6.5; p＜0.0001），≥4％=100％（OR 30.2; p＜0.0001）。聚合的风险因素逐渐增加肿瘤骨钻术后SSI的风险。©2023年作者，在Springer Science+Business Media，LLC的独家许可下，这是Springer Nature的一部分。

This study seeks to expound upon risk factor etiologies for surgical site infection (SSI) and investigate their combinatorial effects on infection rate following craniotomy for neuro-oncologic pathology.Patients who underwent neuro-oncologic craniotomy between 2006 and 2020 were included. Medical records were reviewed to identify the occurrence of wound infection at ≤ 3 months postoperatively. Potential risk factors for infection included tumor pathology, location, anesthesia type, indication, ventricular entry, foreign body, brachytherapy, lumbar drain, prior operation, prior cranial radiation, prior infection, bevacizumab, and medical comorbidities (hypertension, obesity, diabetes, hyperlipidemia, other cancer, cirrhosis). Logistic regression was implemented to determine risk factors for SSI. Chi-square tests were used to assess whether the number of risk factors (e.g., 0, ≥ 1, ≥2, ≥ 3, ≥4) increases the risk of SSI compared to patients with fewer risk factors. The relative increase with each additional risk factor was also evaluated.A total of 1209 patients were included. SSI occurred in 42 patients (3.5%) by 90 days after surgery. Significant risk factors on multivariate logistic regression were bevacizumab (OR 40.84; p < 0.001), cirrhosis (OR 14.20, p = 0.03), foreign body placement (OR 4.06; P < 0.0001), prior radiation (OR 2.20; p = 0.03), and prior operation (OR 1.92; p = 0.04). Infection rates in the combinatorial analysis were as follows: ≥1 risk factor = 5.9% (OR 2.74; p = 0.001), ≥ 2 = 6.7% (OR 2.28; p = 0.01), ≥ 3 = 19.0% (OR 6.5; p < 0.0001), ≥ 4 = 100% (OR 30.2; p < 0.0001).Risk factors in aggregate incrementally increase the risk of postoperative SSI after craniotomy for tumor.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.