Tripartite motif (TRIM)蛋白超家族是一组E3泛素连接酶，具有保守的RING结构域、B-box结构域和螺旋卷曲结构域(RBCC)。它广泛参与各种生理和病理过程，如细胞内信号传导、细胞周期调节、肿瘤发生和先天免疫反应。中枢神经系统疾病由脑病和脊髓疾病组成，残疾和死亡率较高。患者经常无法自理和影响生活质量。最初，TRIM蛋白的功能研究主要集中在癌症方面。然而，近年来越来越多的关注集中在它们在中枢神经系统疾病中所扮演的角色。在本综述中，我们整合了TRIM蛋白在中枢神经系统疾病的病理过程和相关信号通路中所报道的作用，希望为进一步研究以TRIM蛋白为靶点治疗中枢神经系统疾病提供理论依据。TRIM蛋白参与中枢神经系统疾病。TRIM蛋白家族以高度保守的RBCC结构域为特征，包括RING结构域、B-box结构域和螺旋卷曲结构域。最近的研究发现TRIM蛋白与各种中枢神经系统疾病的关系，特别是阿尔茨海默病、帕金森病和缺血性卒中。©2023。作者在Springer Science+Business Media, LLC，Springer Nature的独家许可下发表。

Tripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is widely involved in various physiological and pathological processes, such as intracellular signal transduction, cell cycle regulation, oncogenesis, and innate immune response. Central nervous system (CNS) diseases are composed of encephalopathy and spinal cord diseases, which have a high disability and mortality rate. Patients are often unable to take care of themselves and their life quality can be seriously declined. Initially, the function research of TRIM proteins mainly focused on cancer. However, in recent years, accumulating attention is paid to the roles they play in CNS diseases. In this review, we integrate the reported roles of TRIM proteins in the pathological process of CNS diseases and related signaling pathways, hoping to provide theoretical bases for further research in treating CNS diseases targeting TRIM proteins. TRIM proteins participated in CNS diseases. TRIM protein family is characterized by a highly conserved RBCC domain, referring to the RING domain, the B-box domain, and the coiled-coil domain. Recent research has discovered the relations between TRIM proteins and various CNS diseases, especially Alzheimer's disease, Parkinson's disease, and ischemic stroke.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.