研究动态
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针灸相对于常规护理对患有慢性疼痛的癌症幸存者的睡眠质量的影响:随机临床试验的次要分析。

Effect of acupuncture versus usual care on sleep quality in cancer survivors with chronic pain: Secondary analysis of a randomized clinical trial.

发表日期:2023 Mar 29
作者: Mingxiao Yang, Raymond E Baser, Kevin T Liou, Susan Q Li, Lauren Piulson, Katherine S Panageas, Jun J Mao
来源: CANCER

摘要:

慢性疼痛会对睡眠产生负面影响。目前不清楚针灸止痛是否会对癌症幸存者的睡眠质量产生积极作用。本研究旨在评估针灸相对于常规护理对癌症幸存者伴有共病的睡眠障碍和慢性肌肉骨骼疼痛患者的睡眠质量的影响。研究分析了“个性化电针治疗与耳针治疗的比较研究”随机临床试验的睡眠结果数据。将电针或耳针与常规护理相比较,评估肿瘤幸存者的睡眠质量在10周治疗期间的改善情况,基线为临床意义上的睡眠障碍和慢性肌肉骨骼疼痛。使用匹兹堡睡眠质量指数(PSQI)全球评分来衡量睡眠质量。在268名参与者(平均[标准偏差(SD)]年龄为61.4[12.6]岁,其中191名女性[71.3%],平均[SD]基线PSQI全球评分为10.3[3.3]分)中,与常规护理相比,电针和耳针使PSQI全球评分从基线到10周显著降低:1.42分(95%置信区间[CI],0.45-2.38;p = .004)和1.59分(95% CI,0.62-2.55;p = .001)。针灸组的睡眠质量改善持续时间为随机化后的24周。此外,与常规护理组相比,电针和耳针组中有更多的患者出现临床上显著的睡眠质量改善(分别为41.0%和42.9% vs. 21.4%;p = .044)。在癌症幸存者伴有睡眠障碍和慢性疼痛的患者中,电针和耳针产生了临床相关和持久的睡眠质量改善。这些发现表明,针灸可能是一种基于证据的非药物干预措施,可改善癌症幸存者的疼痛和睡眠健康。此研究分析了一项已发表的随机临床试验的睡眠质量数据,旨在评估电针或耳针相对于常规护理对癌症幸存者止痛效果的影响。这项分析包括268名基线具有共病睡眠障碍和慢性肌肉骨骼疼痛的预先指定的参与者,并发现使用针灸治疗的患者比接受常规护理的患者有更显著的睡眠质量改善。针灸对睡眠质量的改善效果在治疗结束后仍持续存在。©2023美国癌症协会。
Chronic pain negatively affects sleep; it is unclear whether pain relief from acupuncture contributes to sleep quality improvements in cancer survivors. This study aimed to evaluate the effect of acupuncture versus usual care on sleep quality among cancer survivors with comorbid sleep disturbance and chronic musculoskeletal pain.Sleep outcome data from the Personalized Electroacupuncture Versus Auricular Acupuncture Comparative Effectiveness (PEACE) randomized clinical trial were analyzed. Electroacupuncture or auricular acupuncture was compared with usual care for sleep quality improvement over 10 weeks of treatment among cancer survivors with clinically significant sleep disturbance and chronic musculoskeletal pain at baseline. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) global score.Among 268 participants (mean [standard deviation (SD)] age, 61.4 [12.6] years; 191 women [71.3%]; mean [SD] baseline PSQI global score, 10.3 [3.3] points), electroacupuncture and auricular acupuncture resulted in greater reductions in the PSQI global score from baseline to 10 weeks in comparison with usual care: 1.42 points (95% confidence interval [CI], 0.45-2.38; p = .004) and 1.59 points (95% CI, 0.62-2.55; p = .001), respectively. The improvement in sleep quality for the acupuncture groups was sustained for 24 weeks from randomization. Furthermore, a greater proportion of patients in the electroacupuncture and auricular acupuncture groups had clinically meaningful improvement in sleep quality compared to the usual care group (41.0% and 42.9% vs. 21.4%; p = .044).Among cancer survivors with comorbid sleep disturbance and chronic pain, electroacupuncture and auricular acupuncture produced a clinically relevant and persistent improvement in sleep quality. These findings suggest that acupuncture may be an evidence-based nonpharmacologic intervention to improve sleep health for cancer survivors with pain.This study analyzed the sleep quality data from a published randomized clinical trial that evaluated the effect of electroacupuncture or auricular acupuncture versus usual care on pain relief among people who survived cancer. This analysis included a prespecified subgroup of 268 participants with co-occurring sleep disturbance and chronic musculoskeletal pain at baseline and found that patients who used acupuncture for pain relief demonstrated greater improvements in sleep quality compared with patients who received usual care. Sleep quality improvement by acupuncture was sustained after the treatment ended.© 2023 American Cancer Society.