胶质母细胞瘤（GBM）是最常见和具有侵袭性的原发性脑癌。尽管采用包括手术、放射治疗和化疗在内的多种手段治疗，但患者的中位生存期在数十年间一直保持在约15个月。这种情况需要一种创新的治疗方法。利用磁性碳纳米管（mCNTs）和精确的磁场控制，我们报告了一种机械方法来治疗化疗耐药性的胶质母细胞瘤。我们发现，GBM细胞可以吞噬mCNTs，通过旋转磁场的自旋作用，导致细胞死亡。在肿瘤内注入mCNTs，并对其进行时空控制，可以抑制GBM在体内的生长。通过将抗CD44抗体加入到mCNTs中，可以识别GBM细胞表面富含的抗原CD44，增加mCNTs对癌细胞的识别能力，延长了mCNTs在肿瘤内的富集时间，并提高了治疗效果。通过GBM小鼠模型，无论是对替莫唑米德（Temozolomide）的一线还是治疗诱导性耐药性，我们都表明mCNT治疗对于治疗化疗耐药性的GBM非常有效。综上所述，我们建立了基于mCNT的机械纳米外科手术作为GBM治疗选项。

Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Despite multimodal treatment including surgery, radiotherapy, and chemotherapy, median patient survival has remained at ~15 months for decades. This situation demands an outside-the-box treatment approach. Using magnetic carbon nanotubes (mCNTs) and precision magnetic field control, we report a mechanical approach to treat chemoresistant GBM. We show that GBM cells internalize mCNTs, the mobilization of which by rotating magnetic field results in cell death. Spatiotemporally controlled mobilization of intratumorally delivered mCNTs suppresses GBM growth in vivo. Functionalization of mCNTs with anti-CD44 antibody, which recognizes GBM cell surface-enriched antigen CD44, increases mCNT recognition of cancer cells, prolongs mCNT enrichment within the tumor, and enhances therapeutic efficacy. Using mouse models of GBM with upfront or therapy-induced resistance to temozolomide, we show that mCNT treatment is effective in treating chemoresistant GBM. Together, we establish mCNT-based mechanical nanosurgery as a treatment option for GBM.