背景：急性心肌梗塞（AMI）是全球心血管死亡的主要原因之一。最近的研究报告了基因洞穴素-3（CAV3）、抑癌基因2和生长分化因子-15在心血管疾病，尤其是心肌梗塞中的影响，但它们的作用和功能仍不清楚。因此，本研究旨在评估这三种基因在AMI中的表达水平，并了解CAV-3在AMI病理发生中的作用。方法和结果：本横断面研究从50名AMI患者和50名非AMI对照中收集了血样。采用实时PCR检测这三个基因的相对表达水平。使用生物信息学工具进行功能基因富集和蛋白质相互作用。与对照组相比，CAV-3在AMI患者中明显上调。基于计算机的分析确定了CAV-3通过与重要的蛋白质如dysferlin和annexins结合在平滑肌收缩、心脏传导和钙介导的转运中发挥重要作用。结论：这项研究是首次报道了AMI患者中CAV-3的上调情况。这三种基因的表达显著影响了AMI患者的收缩功能。深入了解CAV-3在AMI的病理生理学中的作用至关重要，它可能被证明是一种新的方法。

Background: Acute myocardial infarction (AMI) is one of the world's leading causes of cardiovascular death. Recent studies have reported the influence of the genes caveolin-3 (CAV3), suppression of tumorigenicity 2, and growth differentiating factor-15 in cardiovascular diseases, especially myocardial infarction, but their role and function remain unclear. Hence, this study was designed to evaluate the expression levels of these three genes in AMI and understanding the role of CAV-3 in the pathogenesis of AMI. Methods and Results: Blood samples were collected from 50 AMI patients and 50 non-AMI controls in this cross-sectional study. Relative expression levels of the three genes were performed using real-time PCR. Bioinformatics tools were used for functional gene enrichment and protein-protein interactions. CAV-3 was significantly upregulated among AMI patients compared to controls. In silico analyses identified CAV-3 as playing critical roles in smooth muscle contraction, cardiac conduction, and calcium-mediated transport via binding with essential proteins including dysferlin and annexins Conclusion: This study is a first of its kind, reporting an upregulation of CAV-3 in AMI patients. The expression of all three genes significantly influenced the systolic function of the heart in AMI patients. A more in-depth understanding of CAV-3 in the pathophysiology of AMI is essential and it may prove to be a novel.