我们的微生物群在塑造宿主免疫力方面发挥着至关重要的作用。居住在肠道中的微生物拥有丰富的代谢工具箱，可帮助宿主生理功能。微生物代谢产物，例如短链脂肪酸（SCFA）、嘌呤代谢产物、环二核苷酸、色氨酸衍生物和次生胆汁酸，可在稳态和癌症免疫疗法期间量身定制宿主免疫细胞景观。在过去几年中，微生物群在协助免疫检查点阻滞疗法方面的至关重要的作用愈发明显，最近的研究提供了更详细的机制洞察，揭示微生物及其代谢产物如何控制免疫疗法的结果。本综述总结了最近的研究，介绍了微生物代谢产物在癌症免疫治疗期间如何联合免疫反应。Copyright © 2023 Elsevier Ltd. All rights reserved.

Our microbiota has a critical role in shaping host immunity. Microbes that reside in the gut harbor a large metabolic arsenal to aid in physiological functions of the host. Microbial metabolites, which are products of microbial metabolism, such as short chain fatty acids (SCFA), purine metabolites, cyclic dinucleotides, tryptophan derivatives, and secondary bile acids, can tailor the host immune cell landscape in homeostasis and during cancer immunotherapy. The critical role of the microbiome in aiding immune checkpoint blockade therapies has become clearer over the past few years, with the most recent studies providing more detailed mechanistic insight on how microbes and their metabolites control the outcome of immunotherapy. This review summarizes recent studies on how microbial metabolites orchestrate immune responses during cancer immunotherapies.Copyright © 2023 Elsevier Ltd. All rights reserved.