TREM2是一种髓系细胞受体，在神经炎症和神经退行性疾病的背景下被广泛描述。最近，TREM2作为肿瘤巨噬细胞功能的关键调节因子浮出水面。在不同的小鼠模型中，TREM2缺陷或阻滞提供保护并促进对抗PD1的反应。在人类肿瘤中，表达TREM2的巨噬细胞存在于众多队列和肿瘤类型中，并且通常与免疫抑制和恶性预后相关。在这里，我们提供一个关于TREM2在肿瘤中的影响的概述，考虑到当前的文献，专注于小鼠模型和人类癌症。版权所有©2023 Elsevier Ltd.。

TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.Copyright © 2023 Elsevier Ltd. All rights reserved.