姜黄长期以来不仅是亚洲烹饪不可缺少的一部分，还是治疗伤口、叮咬、烧伤、治疗眼部感染和痤疮的药用草药。姜黄素是活性物质，它们的合成衍生物（即丙二酰姜黄素（DAC）和金属姜黄素络合物）具有极其广泛的药用特性，包括多种重金属的螯合能力、抗氧化活性、抗炎性能、对癌细胞的细胞毒性、抗病毒和抗菌作用、降压和胰岛素敏化作用以及对凋亡的调节作用。上述特性将姜黄素视为潜在治疗肝脏疾病、神经退行性疾病、代谢综合征、血脂异常、心血管疾病、自身免疫疾病、恶性肿瘤以及与金属过载相关疾病的药物。铜对主要生物功能至关重要，然而过量会导致神经退行性疾病等慢性疾病。姜黄素的迷人方法可以通过形成络合物缓解其影响。因此，本综述旨在介绍铜-姜黄素相互作用在不同体外、体外和临床研究中的已有数据。版权所有©2023 Elsevier GmbH。保留所有权利。

Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives (i.e. diacetylcurcumin (DAC) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. The aforementioned properties have put curcumin on spotlight as a potential treatment for ailments such as, hepatic diseases, neurodegenerative diseases, metabolic syndrome, dyslipidemia, cardiovascular disease, auto-immune diseases, malignancies and conditions associated with metal overload. Copper is essential for major biological functions, however, an excess causes chronic ailments including neurodegenerative disorders. The fascinating approach of curcumin could alleviate such effect by forming a complex. Thus, this review aims to present available data on the effect of copper-curcumin interaction in various in vitro, ex-vivo in vivo, and clinical studies.Copyright © 2023 Elsevier GmbH. All rights reserved.