肿瘤标志物浓度低，需要高灵敏度、稳定性和快速检测方法。本文提出并演示了一种由MOFs材料敏化的U形光纤SPR生物传感器。通过在MOFs材料表面修饰U形SPR传感器以增强其灵敏度，并将核酸适体固定在传感器表面上以利用MOFs材料的生物相容性。通过核酸适体的高特异性，MUC1蛋白被识别和检测。测试结果表明，该传感器在MUC1蛋白浓度检测范围为1 pg/ml-100μg/ml时具有对数线性响应，其灵敏度和检测限分别为5.33 nm/log(μg/ml)和0.16 pg/ml。经过MOFs敏化后，传感器的检测灵敏度可以提高1.62倍，检测限可以降低0.75倍。该传感器具有高灵敏度和特异性，具有广泛的肿瘤标记物临床检测应用前景。版权所有 © 2023 Elsevier B.V.。

The concentration of tumor markers is low, which needs a highly sensitive, stable and fast detection method. In this paper, we proposed and demonstrated a U-shape fiber SPR biosensor sensitized by MOFs materials. The surface of the U-shape SPR sensor was modified with MOFs materials to enhance the sensitivity, and the nucleic acid aptamer was immobilized on the sensor surface because of the biocompatibility of MOFs materials. By the high specificity of the nucleic acid aptamer, the MUC1 protein was recognized and detected. The testing results indicate that the sensor has a logarithmic linear response in the MUC1 protein concentration detection range of 1 pg/ml-100 μg/ml, its sensitivity and detection limit are 5.33 nm/log(μg/ml) and 0.16 pg/ml respectively. After being sensitized by MOFs, the detection sensitivity of the sensor can be increased by 1.62 times，the LOD can be decreased by 0.75 times. The sensor has high sensitivity and specificity, which has broad application prospects in clinical detection of tumor markers.Copyright © 2023 Elsevier B.V. All rights reserved.