由转移的“燃尽”精原细胞瘤引起的KELCH11抗体相关的癌性关联性小脑和边缘系统脑炎 - 一种可怕的现象。
Paraneoplastic Kelch-like protein 11 antibody-associated cerebellar and limbic encephalitis caused by metastatic "burned-out" seminoma - A scar(r)y phenomenon.
发表日期：2023 Mar 23
作者：
Benedek Gyongyosi, Rita Magyar-Stang, Timea Takacs, Eszter Szekely, Zsolt Illes, Christine Nilsson, Tamas Gyorke, Peter Barsi, Daniel Juhasz, Balazs Banky, Daniel Bereczki, Jerome Honnorat, Bence Gunda
来源：
Burns & Trauma
摘要：
原句结构不变：The diagnosis of paraneoplastic neurologic syndromes is challenging when the primary tumor masquerades as scar tissue (i.e. "burned-out").Case report.A 45-year-old male patient presented with progressive cerebellar symptoms and hearing loss. Initial screening for malignancy and extensive testing of paraneoplastic and autoimmune neuronal antibodies gave negative results. Repeated whole-body FDG-PET CT revealed a single paraaortic lymphadenopathy, metastasis of a regressed testicular seminoma. Anti-Kelch-like protein-11 (KLHL11) encephalitis was finally diagnosed.Our case highlights the importance of continued efforts to find an often burned-out testicular cancer in patients with a highly unique clinical presentation of KLHL11 encephalitis.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
原发肿瘤伪装成瘢痕组织（即“烧尽”），会使副肿瘤神经症状的诊断变得具有挑战性。个案报告：一名45岁的男性患者出现渐进性小脑症状和听力丧失。肿瘤恶性筛查和广泛的副肿瘤及自身免疫神经抗体检测结果均为阴性。多次全身FDG-PET CT检查显示单个主动脉旁淋巴结肿大，为睾丸精原细胞瘤的转移灶。最终诊断为抗Kelch-like protein-11（KLHL11）脑炎。我们的病例强调了在KLHL11脑炎独特的临床表现中继续努力寻找常常已经烧尽的睾丸癌的重要性。版权所有©2023作者。由Elsevier B.V.出版。保留所有权利。
The diagnosis of paraneoplastic neurologic syndromes is challenging when the primary tumor masquerades as scar tissue (i.e. "burned-out").Case report.A 45-year-old male patient presented with progressive cerebellar symptoms and hearing loss. Initial screening for malignancy and extensive testing of paraneoplastic and autoimmune neuronal antibodies gave negative results. Repeated whole-body FDG-PET CT revealed a single paraaortic lymphadenopathy, metastasis of a regressed testicular seminoma. Anti-Kelch-like protein-11 (KLHL11) encephalitis was finally diagnosed.Our case highlights the importance of continued efforts to find an often burned-out testicular cancer in patients with a highly unique clinical presentation of KLHL11 encephalitis.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.