自身免疫性脑炎误诊和模仿。
Autoimmune encephalitis misdiagnosis and mimics.
发表日期：2023 Mar 16
作者：
Alessandro Dinoto, Pietro Zara, Sara Mariotto, Sergio Ferrari, Eoin P Flanagan, Adrian Budhram, Daniela Orellana, Davide Turilli, Paolo Solla, Gregory S Day, Elia Sechi, A Sebastian Lopez-Chiriboga
来源：
BIOMEDICINE & PHARMACOTHERAPY
摘要：
自身免疫性脑炎（AE）的诊断需要合理排除其他疾病。本研究旨在探查AE的模仿者和误诊，因此我们进行了独立的PubMed搜索，以寻找AE的模仿者或被误诊为AE的另一种神经疾病的患者。共纳入了58项研究和66名患者。肿瘤性（n = 17）、感染性（n = 15）、遗传性（n = 13）、神经退行性（n = 8）、其他神经系统（n = 8）或全身自身免疫性（n = 5）疾病被误诊为AE。未能满足AE诊断标准、非典型神经影像学表现、非炎性脑脊液发现、非特异性自身抗体特异性和对免疫治疗的部分反应是主要的干扰因素。 版权所有©2023 Elsevier B.V.保留所有权利。
The diagnosis of autoimmune encephalitis (AE) requires reasonable exclusion of other conditions. The aim of this study is to characterize mimickers and misdiagnoses of AE, thus we performed an independent PubMed search for mimickers of AEs or patients with alternative neurological disorders misdiagnosed as AE. Fifty-eight studies with 66 patients were included. Neoplastic (n = 17), infectious (n = 15), genetic (n = 13), neurodegenerative (n = 8), and other neurological (n = 8) or systemic autoimmune (n = 5) disorders were misdiagnosed as AE. The lack of fulfillment of diagnostic criteria for AE, atypical neuroimaging findings, non-inflammatory CSF findings, non-specific autoantibody specificities and partial response to immunotherapy were major confounding factors.Copyright © 2023 Elsevier B.V. All rights reserved.