八种未描述的倍半萜香豆素（1-8）和已知的20种化合物（9-28）已从新疆阿尔金山香豆素（Ferula sinkiangensis K.M. Shen）的地上部分中分离出来。通过UV、IR、HRESIMS、1D和2D NMR数据的全面分析，确定了它们的结构。化合物1的绝对构型通过单晶X射线衍射确定，而化合物2-8的绝对构型则通过实验和计算的静电圆二色性光谱比较确定。化合物2是来自香豆素属的首个过氧化倍半萜香豆素，而化合物8具有不寻常的5’，8’-过氧化桥。Griess反应结果表明，化合物18显著降低了脂多糖激活的RAW 264.7巨噬细胞的一氧化氮产量，IC50值为2.3μM，ELISA结果显示，化合物18有效抑制了肿瘤坏死因子-α、白细胞介素（IL）-1β和IL-6的表达。Copyright © 2023. Elsevier Ltd. 发布。

Eight undescribed sesquiterpene coumarins (1-8) and twenty known ones (9-28), were isolated from the aerial parts of Ferula sinkiangensis K. M. Shen. Their structures were elucidated based on the comprehensive analysis of UV, IR, HRESIMS, 1D, and 2D NMR data. The absolute configuration of 1 was determined by single crystal X-Ray diffraction, while the absolute configurations of 2-8 were determined by comparisons of experimental and calculated electrostatic circular dichroism spectra. Compound 2 is the first hydroperoxy sesquiterpene coumarin from the genus Ferula, while compound 8 has an unusual 5',8'-peroxo bridge. Griess reaction results indicated compound 18 significantly decreased nitric oxide production of the lipopolysaccharide-stimulated RAW 264.7 macrophages with an IC50 value of 2.3 μM, and ELISA results revealed that compound 18 effectively inhibited tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 expressions.Copyright © 2023. Published by Elsevier Ltd.