肝病导致200万人死亡，占全球死亡人数的4％（每25人中有1人死于肝病）；约2/3的肝脏相关死亡发生在男性。死亡主要是由于肝硬化和肝细胞癌并发症所致，急性肝炎造成的死亡比例较小。全球肝硬化的最常见原因与病毒性肝炎，酒精和非酒精性脂肪肝（NAFLD）有关。肝病毒是急性肝炎大多数病例的病因，但药物引起的肝损伤越来越占了很大比例。这一版全球肝病负担的更新版本主要关注有重要新信息可用的领域，如与酒精相关的肝病，NAFLD，病毒性肝炎和HCC。我们还专门致力于非洲地区肝病的负担，这是这类文件通常忽视的一个地区。版权所有©2023 Elsevier B.V. 发布。

Liver disease accounts for 2 million deaths and is responsible for 4% of all deaths (1 out of every 25 deaths worldwide); approximately 2/3 of all liver related deaths occur in men. Deaths are largely attributable to complications of cirrhosis and hepatocellular carcinoma, with acute hepatitis accounting for a smaller proportion of deaths. The most common causes of cirrhosis worldwide are related to viral hepatitis, alcohol, and nonalcoholic fatty liver disease (NAFLD). Hepatotropic viruses are the etiological factor in most cases of acute hepatitis, but drug-induced liver injury increasingly accounts for a significant proportion of cases. This iteration of the global burden of liver disease is an update of the 2019 version and focuses mainly on areas where significant new information is available like alcohol-associated liver disease, NAFLD, viral hepatitis, and HCC. We also devote a separate section to the burden of liver disease in Africa, an area of the world typically neglected in such documents.Copyright © 2023. Published by Elsevier B.V.