应激颗粒（SGs）是非翻译信使核糖核蛋白体（mRNPs）组成的非膜亚细胞器，在癌细胞（包括胰腺癌，尤其是胰腺导管癌（PDAC），5年生存率仅为10%）中响应各种环境刺激而聚集形成，但相关SGs和胰腺癌的研究尚未编编译。本文将探讨SGs的动态及其在胰腺癌中所起的积极作用，例如SGs促进PDAC的生存能力以及抑制凋亡，同时强调SGs在胰腺癌中与KRAS、P53和SMAD4等特征突变之间的关联以及SGs在抗肿瘤药物抗性中的功能。这种新型的压力管理技术可能会为未来的治疗选择打开大门。 版权所有 © 2023 Elsevier B.V. 发行.

Stress granules (SGs), non-membrane subcellular organelles made up of non-translational messenger ribonucleoproteins (mRNPs), assemble in response to various environmental stimuli in cancer cells, including pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC) which has a low 5-year survival rate of 10%. The pertinent research on SGs and pancreatic cancer has not, however, been compiled. In this review, we talk about the dynamics of SGs and their positive effects on pancreatic cancer such as SGs promote PDAC viability and repress apoptosis, meanwhile emphasizing the connection between SGs in pancreatic cancer and signature mutations such KRAS, P53, and SMAD4 as well as the functions of SGs in antitumor drug resistance. This novel stress management technique may open the door to better treatment options in the future.Copyright © 2023. Published by Elsevier B.V.