芸香科是由大约2100种分布在澳大拉西亚、美洲和南非的热带和温带地区的154个属表达的一家族。该家族的大量物种被用作民间药物。文献将芸香科描述为天然和生物活性化合物（如萜类、类黄酮和尤其是香豆素）的重要来源。迄今为止，过去十二年中已从芸香科中分离和鉴定了655种香豆素中的大多数，在生物和药理活性方面显示出不同的活性。有研究表明，来自芸香科的香豆素对癌症、炎症、传染病以及内分泌和胃肠状况的治疗显示出活性。虽然香豆素被认为是多才多艺的生物活性分子，但到目前为止，还没有关于芸香科香豆素的汇编信息，展示这些化合物在所有维度上的效力和各属之间的化学相似性。本综述涵盖了从2010年至2022年所分离的芸香科香豆素的相关研究，并概述了这些化合物的药理活性的当前数据。此外，还使用PCA和HCA方法统计讨论了芸香科属之间化学的配置和相似性。版权所有©2023 Elsevier B.V.发表。

Rutaceae is a family expressed by approximately 2100 species distributed in 154 genera widespread in tropical and temperate regions of Australasia, America, and South Africa. Substantial species of this family are employed as folk medicines. The literature describes the Rutaceae family as a great source of natural and bioactive compounds like terpenoids, flavonoids, and, especially, coumarins. To data, 655 coumarins were isolated and identified from Rutaceae in the past twelve years and, most of them, showed different biological and pharmacological activities. There are studies with coumarins from Rutaceae indicating that these compounds showed activity against cancer, inflammation, infectious diseases, and in the treatment of endocrinal and gastrointestinal conditions. Although coumarins are considered versatile bioactive molecules, until the present, there is no compiled information about coumarins from the Rutaceae family demonstrating the potency of these compounds in all dimensions and chemical similarities among the genera. The present review covers the relevant studies dealing with isolation of Rutaceae coumarins from 2010 until 2022 and outlines the current data on pharmacological activities these coumpounds. Additionally, the chemical disposition and similarity among Rutaceae genera are also statistically discussed employing PCA and HCA methods.Copyright © 2023. Published by Elsevier B.V.