生物学癌症表征、靶向全身治疗和多模态治疗策略的进展，已将脊椎转移的放射治疗目标由短期缓解转变为长期症状控制和并发症预防。本文概述了脊柱立体定向放射治疗（SBRT）方法以及SBRT用于癌症患者的临床结果，包括疼痛性椎体转移、转移性脊髓压迫、少量转移性疾病以及再次放疗情况下的治疗。文章比较了剂量增强的SBRT治疗效果与常规放疗的结果，并讨论了患者选择标准。虽然脊柱SBRT后严重毒性的发生率较低，但是文章总结了最小化椎体压缩骨折、放射性髓病、神经丛障碍和筋炎风险的策略，以优化SBRT在脊柱转移治疗的多学科管理中的应用。版权所有©2023年作者。Elsevier Inc.保留所有权利。

Progress in biological cancer characterization, targeted systemic therapies and multimodality treatment strategies have shifted the goals of radiotherapy for spinal metastases from short-term palliation to long-term symptom control and prevention of compilations. This article gives an overview of the spine stereotactic body radiotherapy (SBRT) methodology and clinical results of SBRT in cancer patients with painful vertebral metastases, metastatic spinal cord compression, oligometastatic disease and in a reirradiation situation. Outcomes after dose-intensified SBRT are compared with results of conventional radiotherapy and patient selection criteria will be discussed. Though rates of severe toxicity after spinal SBRT are low, strategies to minimize the risk of vertebral compression fracture, radiation induced myelopathy, plexopathy and myositis are summarized, to optimize the use of SBRT in multidisciplinary management of vertebral metastases.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.