芽孢菌病是一种真菌感染，由接触携带芽孢菌Sporothrix schenckii的土壤或吸入真菌孢子引起。皮肤是最常暴露的器官，使芽孢菌病成为主要的皮肤病。文献中描述的许多报告表明芽孢菌病与皮肤鳞状细胞癌有关，最初的芽孢菌病诊断和治疗后发生皮肤鳞状细胞癌的关系。相反，也有证据表明皮肤癌诊断后出现芽孢菌病，即使在癌症化疗后，这指向癌症化疗导致免疫反应减弱，从而被Sporothrix schenckii攻击和感染。我们还提出并关注炎症作为芽孢菌病、癌症甚至癌症转移的联系。与炎症相关的IL-6、IFN-γ、自然杀伤细胞和M2型巨噬细胞可能在机械上联系芽孢菌病和癌症，特别是皮肤鳞状细胞癌。这些与炎症相关的因子/细胞的表观遗传调节提高了芽孢菌病的表观遗传调节的可能性，这在现有文献中尚未描述。因此，炎症的临床管理可能不仅对芽孢菌病有效，而且对相关的皮肤鳞状细胞癌和可能的淋巴结转移也有效。版权所有©2023 Elsevier Ltd.

Sporotrichosis, a fungal disease, is caused by exposure to soil that harbors Sporothrix schenckii or through inhalation of fungal spores. Skin is the most frequently exposed organ making sporotrichosis a primarily dermal disease. Many described reports in the literature suggest a connection of sporotrichosis with cutaneous squamous cell carcinoma with some connection between initial sporotrichosis diagnosis and treatment followed by development of cutaneous squamous cell carcinoma at the very site. Conversely, there is also evidence for sporotrichosis subsequent to skin cancer diagnosis, even after cancer chemotherapy, which points towards weakening of immune response by cancer chemotherapy leading to attack and infection by Sporothrix schenckii. We also propose and focus on inflammation as the connection between sporotrichosis, cancer and even the metastatic spread of cancer. Inflammation-associated IL-6, IFN-γ, natural killer cells and M2-macrophages possibly mechanistically link sporotrichosis with cancer, particularly cutaneous squamous cell carcinoma. These inflammation related factors/cells are regulated epigenetically raising the possibility of epigenetic regulation of sporotrichosis, which has not been described yet in the available literature. Clinical management of inflammation may thus be effective strategy not just against sporotrichosis but also the related onset of cutaneous squamous cell carcinoma and possibly its metastasis to lymph nodes.Copyright © 2023. Published by Elsevier Ltd.