三阴性乳腺癌仍然是妇女死亡的主要原因之一，占所有癌症死亡的7％。治疗肿瘤的电场是低能量，低频振荡的电场，可引起神经胶质母细胞瘤、非小细胞肺癌和卵巢癌有抗增殖作用。目前只有极少关于肿瘤治疗场对三阴性乳腺癌的影响，并已知肿瘤治疗场的研究只使用了低于3V / cm的电场强度。我们已经开发出一种内部场送达装置，能够进行高度定制，以探索更多样化的电场和治疗参数。此外，我们还调查了肿瘤治疗场治疗三阴性乳腺癌和人类乳腺上皮细胞之间的选择性。肿瘤治疗场在1至3V / cm电场强度下对三阴性乳腺癌细胞系显示出最有效的疗效，而对上皮细胞几乎没有影响。这些结果为向三阴性乳腺癌提供肿瘤治疗场提供了明确的治疗窗口。©2023年。作者（S）。

Triple-negative breast cancer continues to be one of the leading causes of death in women, making up 7% of all cancer deaths. Tumor-treating electric fields are low-energy, low-frequency oscillating electric fields that induce an anti-proliferative effect on mitotic cells in glioblastoma multiforme, non-small cell lung cancer, and ovarian cancer. Little is known about effects of tumor-treating fields on triple-negative breast cancer and known research for tumor-treating fields only utilizes low (< 3 V/cm) electric field intensities.We have developed an in-house field delivery device capable of high levels of customization to explore a much wider variety of electric field and treatment parameters. Furthermore, we investigated the selectivity of tumor-treating field treatment between triple-negative breast cancer and human breast epithelial cells.Tumor-treating fields show greatest efficacy against triple-negative breast cancer cell lines between 1 and 3 V/cm electric field intensities while having little effect on epithelial cells.These results provide a clear therapeutic window for tumor-treating field delivery to triple-negative breast cancer.© 2023. The Author(s).