恶性黑色素瘤是一种预后不良且高度抵抗传统治疗的皮肤癌。7,8-二羟基黄酮（7,8-DHF）已在多种癌症中显示出抗癌、抗炎、抗氧化和药理作用。然而，在黑色素瘤中神经节苷脂表达与7,8-DHF的抗癌作用之间的关系还不完全清楚。在本研究中，7,8-DHF表现出特异性的抗增殖、抗迁移和G2/M期细胞周期阻滞作用，在两种黑色素瘤癌细胞株中引起线粒体功能障碍和凋亡，使其成为抗黑色素瘤治疗的强有力候选药物。此外，我们证实7,8-DHF显著降低了神经节苷脂GD3及其合成酶的表达水平，这些都已知密切涉及癌症的发生。综上所述，我们的发现表明7,8-DHF可能是治疗恶性黑色素瘤的强有力抗肿瘤药物候选人。©2023.作者及出版者

Malignant melanoma is a skin cancer with poor prognosis and high resistance to conventional treatment. 7,8-dihydroxyflavone (7,8-DHF) has shown anti-carcinogenic, anti-inflammatory, anti-oxidant, and pharmacological effects in several types of cancer. However, the relationship between ganglioside expression and the anti-cancer effects of 7,8-DHF in melanoma is not fully understood. In the present study, 7,8-DHF exhibits specific anti-proliferation, anti-migration, and G2/M phase cell-cycle arrest effects on both melanoma cancer cell lines, and induces mitochondrial dysfunction and apoptosis, making it a potent candidate for anti-melanoma treatment. Furthermore, we confirmed that 7,8-DHF significantly reduces the expression levels of ganglioside GD3 and its synthase, which are known to be closely involved in carcinogenesis. Taken together, our findings suggest that 7,8-DHF may be a potent anti-cancer drug candidate for the treatment of malignant melanoma.© 2023. The Author(s).