研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

子宫内膜异位症卵巢和子宫同步性子宫内膜类癌保留手术后成功体外受精。

Successful in vitro fertilization following conservative surgery for synchronous endometrioid tumor of ovary and uterus.

发表日期:2023 Mar 29
作者: Vanita Suri, Ramandeep Bansal, Neelam Aggarwal, Pooja Sikka, Seema Chopra, Subhash Chandra Saha, Nalini Gupta, Bhavana Rai
来源: Journal of Ovarian Research

摘要:

在同时患有卵巢和子宫内膜癌的女性中成功怀孕结果非常罕见。我们报道了一位因同步子宫内膜和卵巢癌而接受保守治疗的年轻女性成功怀孕的情况。这位30岁的未生育女士接受了探查性剖腹手术、左侧输卵管和卵巢切除术以及宫腔镜刮除手术,以治疗左侧附件肿块。组织学检查显示左侧卵巢内膜样癌和被切除息肉中度分化腺癌。她接受了分期手术和宫腔镜检查,确认以上发现,并没有发现进一步的肿瘤扩散。她接受了高剂量口服孕激素(乙酰美格莉酮,160mg)和3.75mg/月的乙酰鹿胎瘤释放激素注射剂治疗三个月,以及四个疗程的碳酸铂和紫杉醇化疗,之后又接受了三个月的月经周期注射乙酰鹿胎瘤释放激素。在自然受孕失败后,她进行了六个周期的促排卵治疗,以及宫腔内人工授精,但都未能成功。最后她接受了供卵试管婴儿技术,并在怀孕37周时行剖腹产,生下一个健康的婴儿,体重为2.7kg。手术中发现了一个5×6cm的右侧卵巢囊肿,在穿刺时排出了巧克力色的液体,并进行了囊肿切除术。组织学检查显示右侧卵巢为内膜样囊肿。为了保留其生育能力,子宫得以保留。她正接受定期随访,出生后9个月的情况正常。她每三个月注射一次的针剂为醋酸甲羟孕酮沉淀悬液。© 2023.作者。
Successful pregnancy outcome in women with synchronous ovarian and endometrial cancers is very rare. We report successful pregnancy outcome in a young woman managed conservatively for synchronous endometrial and ovarian cancer.Thirty years old nulliparous lady presented following exploratory laparotomy, left salpingo-oophorectomy and hysteroscopic polypectomy for left adnexal mass. Histology revealed endometrioid carcinoma of left ovary and moderately differentiated adenocarcinoma in the resected polyp. She underwent staging laparotomy along with hysteroscopy which confirmed above findings without any evidence of further tumor spread. She was treated conservatively with high dose oral progestin (megestrol acetate, 160 mg) and leuprolide acetate 3.75 mg monthly injections for three months along with four cycles of carboplatin and paclitaxel based chemotherapy followed by monthly injection of leuprolide for further three months. After failure of spontaneous conception, she underwent ovulation induction for six cycles along with intrauterine insemination which failed. She underwent in vitro fertilization with donor egg followed by elective cesarean section at 37 weeks of gestation. She delivered a healthy baby of weight 2.7 kg. Intraoperatively 5 × 6 cm right ovarian cyst was found which drained chocolate coloured fluid on puncture and cystectomy was carried out. Histological examination revealed endometrioid cyst of right ovary. Uterus was spared as she wanted to preserve her fertility. She is being followed periodically and is normal nine months following delivery. She is on injection Depot medroxy progesterone acetate once every three months.© 2023. The Author(s).