转化性乳腺癌是全球女性死亡最常见和广为人知的原因之一。炎性肿瘤细胞和其他癌症特征塑造了乳腺癌的转移形式和扩散。考虑到这些因素，来自肿瘤微环境的各种成分中，一种称为Th-17的促炎性浸润细胞在乳腺癌增殖、浸润和转移中发挥着重要作用。已经证明，Th-17生成的多功能促炎细胞因子IL-17在乳腺癌的转移形式中被上调。最近的研究更新说明，慢性炎症和细胞因子、趋化因子等介质是许多人类癌症，包括乳腺癌的原因标志。因此，IL-17及其多重下游信号分子成为了研究关注的中心，以开发强效的癌症治疗选择。它们提供了有关IL-17激活的MAPK在通过NF-kB介导的MMP信号表达导致肿瘤细胞增殖和转移的作用的信息。总体而言，本综述文章强调了IL-17A及其中间信号分子（如ERK1/2、NF-kB、MMP和VEGF）作为预防和治疗乳腺癌的潜在分子靶点。版权所有©2023 Shibabaw、Teferi和Ayelign。

Metastatic breast cancer is one of the most common and well-known causes of death for women worldwide. The inflammatory tumor cell and other cancer hallmarks dictate the metastatic form and dissemination of breast cancer. Taking these into account, from various components of the tumor microenvironment, a pro-inflammatory infiltrative cell known as Th-17 plays an immense role in breast cancer proliferation, invasiveness, and metastasis. It has been demonstrated that IL-17, a pleiotropic pro-inflammatory cytokine generated by Th-17, is upregulated in a metastatic form of breast cancer. Recent research updates stated that chronic inflammation and mediators like cytokines and chemokines are causative hallmarks in many human cancers, including breast cancer. Therefore, IL-17 and its multiple downward signaling molecules are the centers of research attention to develop potent treatment options for cancer. They provide information on the role of IL-17-activated MAPK, which results in tumor cell proliferation and metastasis via NF-kB-mediated expression of MMP signaling. Overall, this review article emphasizes IL-17A and its intermediate signaling molecules, such as ERK1/2, NF-kB, MMPs, and VEGF, as potential molecular targets for the prevention and treatment of breast cancer.Copyright © 2023 Shibabaw, Teferi and Ayelign.