免疫检查点抑制剂（ICIs）靶向T细胞抑制通路的使用彻底改变了癌症治疗。然而，ICIs可能通过影响T细胞的再激活引起进行性特应性皮炎（AD）。广泛认识到T细胞在AD发病机制中发挥了关键作用。T细胞共同信号通路调节T细胞激活，其中共同信号分子对于决定T细胞对抗原反应的程度至关重要。鉴于ICIs在癌症治疗中的不断增加，需要及时概述T细胞共同信号分子在AD中的作用。在本文中，我们强调这些分子在AD发病机制中的重要性。我们还讨论了靶向T细胞共同信号通路治疗AD的潜力，以及存在的未解决问题和现有限制。更好地理解T细胞共同信号通路将有助于研究AD的机制、预后评估和治疗。版权所有©2023年郑，施和邹。

The use of immune checkpoint inhibitors (ICIs) targeting the T cell inhibitory pathways has revolutionized cancer treatment. However, ICIs might induce progressive atopic dermatitis (AD) by affecting T cell reactivation. The critical role of T cells in AD pathogenesis is widely known. T cell co-signaling pathways regulate T cell activation, where co-signaling molecules are essential for determining the magnitude of the T cell response to antigens. Given the increasing use of ICIs in cancer treatment, a timely overview of the role of T cell co-signaling molecules in AD is required. In this review, we emphasize the importance of these molecules involved in AD pathogenesis. We also discuss the potential of targeting T cell co-signaling pathways to treat AD and present the unresolved issues and existing limitations. A better understanding of the T cell co-signaling pathways would aid investigation of the mechanism, prognosis evaluation, and treatment of AD.Copyright © 2023 Zheng, Shi and Zou.