近年来，结直肠癌（CRC）的发病率和死亡率不断上升，因此急需发现新药物以增强CRC治疗中的药物敏感性并逆转药物耐受性。基于此，本研究着重于理解CRC对药物的化疗耐药机制，探索不同传统中药在恢复CRC对化疗药物的敏感性中的潜力。此外，恢复敏感性涉及到的机制，例如通过作用于传统化学药物的靶点、辅助药物活化、提高抗癌药物的细胞内积累、改善肿瘤微环境、缓解免疫抑制和消除可逆修饰如甲基化等，已经得到深入讨论。此外，研究了中药与抗癌药物在减少毒性、提高效能、调节新的细胞死亡方式和有效阻断药物耐药机制方面的作用。我们旨在探索中药作为抗CRC药物的增敏剂的潜力，为开发一种新的天然、低毒和高效的对抗CRC化疗耐药的增敏剂做出努力。版权所有 ©2023林、杨、杨、张和黄。

In recent years, the incidences and mortalities from colorectal cancer (CRC) have been increasing; therefore, there is an urgent need to discover newer drugs that enhance drug sensitivity and reverse drug tolerance in CRC treatment. With this view, the current study focuses on understanding the mechanism of CRC chemoresistance to the drug as well as exploring the potential of different traditional Chinese medicine (TCM) in restoring the sensitivity of CRC to chemotherapeutic drugs. Moreover, the mechanism involved in restoring sensitivity, such as by acting on the target of traditional chemical drugs, assisting drug activation, increasing intracellular accumulation of anticancer drugs, improving tumor microenvironment, relieving immunosuppression, and erasing reversible modification like methylation, have been thoroughly discussed. Furthermore, the effect of TCM along with anticancer drugs in reducing toxicity, increasing efficiency, mediating new ways of cell death, and effectively blocking the drug resistance mechanism has been studied. We aimed to explore the potential of TCM as a sensitizer of anti-CRC drugs for the development of a new natural, less-toxic, and highly effective sensitizer to CRC chemoresistance.Copyright © 2023 Lin, Yang, Yang, Zhang and Huang.