我们旨在评估肝移植（LT）计划对接受肝切除（LR）和非治愈意图治疗的肝细胞癌（HCC）患者预后的影响。LT计划拥有一系列资源和服务，可以积极影响HCC患者的预后。从国家癌症数据库中选择了在2004年至2018年期间接受LT、LR、放疗（RT）或化疗（CTx）治疗的HCC患者。被定义为有LT计划的机构是至少连续5年进行一次或多次LT的机构。中心按照医院的手术量分层。通过倾向得分匹配以实现协变量平衡来评估LT计划的影响。总共发现了71,735名患者，其中7,997名接受了LT（11.1％），12,683名接受了LR（17.7％），15,675名接受了RT（21.9％），35,380名接受了CTx（49.3％）。在共计1,267个不同机构中，有94个（7.4％）被归类为LT计划。被认定为LT计划也与高手术量和非治愈意图治疗有关（两者P＜0.001）。倾向得分匹配后，LT计划与LR和非治愈意图治疗患者的更好生存率有关。尽管医院手术量也与预后改善有关，但LT计划与非治愈意图治疗中的额外生存益处有关。另一方面，接受LR的患者没有观察到这样的益处。LT计划的存在与更高手术量和非治愈意图治疗有关。此外，被认定为LT计划对接受RT / CTx治疗的患者的预后产生“光环效应”，超越了手术量效应。版权所有©2023 Wolters Kluwer Health，Inc。保留所有权利。

We sought to evaluate the impact of liver transplantation (LT) programs on the prognosis of hepatocellular carcinoma (HCC) patients who underwent liver resection (LR) and non-curative intent treatment.LT programs have an array of resources and services that would positively affect the prognosis of patients with HCC.Patients who underwent LT, LR, radiotherapy (RT), or chemotherapy (CTx) for HCC between 2004 to 2018 were included from the National Cancer Database. Institutions with LT programs were defined as those that performed one or more LT for at least 5 years. Centers were stratified by hospital volume. The impact of LT programs was assessed after propensity score matching to achieve covariate balance.A total of 71,735 patients were identified, of which 7,997 received LT (11.1%), 12,683 LR (17.7%), 15,675 RT (21.9%), and 35,380 CTx (49.3%). Among a total of 1,267 distinct institutions, 94 (7.4%) were categorized as LT programs. Designation as a LT program was also associated with a high-volume of LR and non-curative intent treatment (both P<0.001). After propensity score matching, LT programs were associated with better survival among LR and non-curative intent treatment patients. Although hospital volume was also associated with improved prognosis, LT programs were associated with additional survival benefit in non-curative intent treatment. On the other hand, no such benefit was noted in patients who underwent LR.The presence of an LT program was associated with a higher volume of LR and non-curative intent treatment. Furthermore, designation as a LT program has a "halo effect" on the prognosis of patients undergoing RT/ CTx that goes beyond the procedure-volume effect.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.