疼痛是镰状细胞贫血（SCD）的线索性临床表现，导致住院、心理后遗症和健康相关生活质量降低。这篇系统文献综述的目的是评估非药物干预在减轻患有SCD的儿童相关疼痛方面的功效。按照系统综述和荟萃分析最佳报告项目标准，我们进行了全面的文献检索，直至2022年10月，以确定研究儿童（21岁以下）患有SCD的疼痛频率和/或强度以及镇痛和卫生服务使用方面的非药物干预效果的研究。随机对照试验（RCT）和准实验设计（QED）研究均被考虑纳入。共包括10篇文章（5篇RCT和5篇QED研究），共422名参与者。它们研究了认知行为疗法（CBT）（n = 5）、生物反馈（n = 2）、按摩（n = 1）、虚拟现实（n = 1）和瑜伽（n = 1）。大多数干预措施为心理干预（n = 7），在门诊诊所（n = 6）中进行。CBT和生物反馈在门诊设置中显著降低了SCD相关疼痛的频率和/或强度，而虚拟现实和瑜伽则在住院设置中显著减少了疼痛。生物反馈也显著减少了镇痛用量。没有包括的文章报道了降低了卫生服务使用率。非药物干预可能有效地减少患有SCD的儿科患者的疼痛。但是，由于包括的研究的异质性，无法进行定量分析。在等待进一步支持的证据时，医疗保健提供者应该考虑将这些干预措施作为全面疼痛管理策略的有价值的一部分实施。© 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.

Pain is the clinical hallmark of sickle cell disease (SCD) leading to hospitalization, psychological sequelae and a decreased health-related quality of life. The aim of this systematic literature review is to evaluate the efficacy of non-pharmacological interventions in reducing sickle cell related pain in children with SCD.Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a comprehensive literature search up until October 2022 was performed to identify studies that investigated the efficacy of non-pharmacological interventions on (1) pain frequency and/or intensity, and (2) analgesic and health service use in children with SCD until the age of 21. Both randomized controlled trials (RCTs) and quasi-experimental designed (QED) studies were considered for inclusion.Ten articles (five RCTs and five QED studies) with 422 participants were included. They investigated cognitive behavioural therapy (CBT) (n = 5), biofeedback (n = 2), massage (n = 1), virtual reality (n = 1) and yoga (n = 1). The majority of the interventions were psychological (n = 7) and were performed in the outpatient clinic (n = 6). CBT and biofeedback significantly reduced frequency and/or intensity of SCD-related pain in outpatient settings, while virtual reality and yoga significantly reduced pain in inpatient settings. Biofeedback also significantly reduced analgesic use. None of the included articles reported reduced health service use.Non-pharmacological interventions may be effective in reducing pain in paediatric patients with SCD. However, due to the heterogeneity of the included studies a quantitative analysis could not be performed. Awaiting further supporting evidence, healthcare providers should consider implementing these interventions as valuable part of a comprehensive pain management strategy plan.© 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.