研究动态
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麻醉和癌症:不仅是为了避免应激反应的事情。

Anesthesia and Cancer: Something More than Avoid Stress Response.

发表日期:2023 Mar 28
作者: Aida Raigon Ponferrada, Salvador Romero Molina, Juan Carlos Molina Ruiz, Gomez Maldonado J, Jose Luis Guerrero Orriach
来源: PHARMACOLOGY & THERAPEUTICS

摘要:

目前,癌症患者已经成为手术室中数量最多的患者。麻醉药物的影响已经成为众多研究的主题,它们表明使用某些药物可能会影响预后和生存。通过研究这些药物对不同代谢途径和其作用机制的影响,我们可以更好地理解它们如何影响各种癌症发生的标志,确定它们对癌症进展的潜在影响。一些作用途径在肿瘤学中是广为人知的,是特定治疗的靶点,如PI3K/AKT/mTOR、EGFR和Wnt/ β-catenin。这篇综述通过细胞信号通路、基因、免疫和转录途径对麻醉药物和肿瘤细胞系之间的相互作用进行了彻底的剖析。通过这些潜在机制,它旨在阐明麻醉药物选择的效果及其对肿瘤手术预后的潜在影响。版权所有©Bentham Science Publishers;如有任何疑问,请发送电子邮件至epub@benthamscience.net。
Currently, patients with tumor pathologies have become the most numerous patients in operating rooms. The influence of anesthetics drugs has been the subject of numerous studies, they have shown that the use of certain drugs may have impact on prognosis and survival. By investigating the action of these drugs on different metabolic pathways and their mechanisms of action, we can better understand how they influence various hallmarks of carcinogenesis and determine their potential impact on cancer progression. Some of the pathways of action are widely known within oncology, being targets of specific treatments such as PI3k/AKT/mTOR, EGFR and Wnt/ β-catenin. This review performs a thorough dissection of the interaction between anesthetic drugs and oncological cell lines through cell signaling pathways, genetic, immune and transcriptomic pathways. Through these underlying mechanisms, it aims to clarify the effect of the choice of anesthetic drug and its potential influence on the prognosis of oncological surgery.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.