研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

利用抗菌肽的治疗潜力治疗癌症:艺术的状态。

Harnessing the Therapeutic Potential of Antimicrobial peptides for cancers: State of the art.

发表日期:2023 Mar 28
作者: Maryam Mahjoubin-Tehran, Samaneh Rezaei, Seyed Hamid Aghaee-Bakhtiari, Amirhossein Sahebkar, Reza Kazemi Oskuee, Ali Mahmoudi, Amin Jalili
来源: Cell Death & Disease

摘要:

尽管癌症治疗取得了重大突破,但癌症仍然是全球健康方面的严重问题,每年夺去数千条生命。然而,药物耐受性和不良反应是传统癌症治疗方法的主要问题。因此,发现具有不同作用机制的新型抗癌剂是一项关键要求,也存在重大障碍。各种生物体中都存在抗微生物肽(AMPs),它们被认为是对微生物病原体感染的防御武器。令人惊讶的是,它们也能够杀死多种癌细胞。这些强大的肽能够导致胃肠道、泌尿道和生殖癌细胞系的细胞死亡。为突显AMPs的抗癌特性,本文总结了对它们对癌细胞系的影响进行的研究。版权所有© Bentham Science Publishers;如有任何疑问,请发送电子邮件至epub@benthamscience.net。
Despite significant breakthroughs in cancer treatment, cancer remains a serious global health concern that takes thousands of lives each year. Still, drug resistance and adverse effects are the main problems in conventional cancer therapeutic approaches. Thus, the discovery of new anti-cancer agents with distinct mechanisms of action is a critical requirement that offers significant obstacles. Antimicrobial peptides (AMPs), which can be found in various forms of life, are recognized as defensive weapons against infections of microbial pathogens. Surprisingly, they are also capable of killing a variety of cancer cells. These powerful peptides can cause cell death in the gastrointestinal, urinary tract, and reproductive cancer cell lines. To emphasize the anti-cancer properties of AMPs, we summarize the research that examined their impact on cancer cell lines in this review.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.