脂肪酸代谢重编程已经成为抗肿瘤免疫反应的重要调节因子，并有大量证据表明其能够影响免疫细胞的分化和功能。因此，取决于肿瘤微环境中产生的代谢信号，肿瘤脂肪酸代谢可以倾斜炎症信号的平衡，以促进或破坏抗肿瘤免疫反应。放射治疗产生的活性氧自由基等氧化应激因素可以改变肿瘤的能量供应，这表明放射治疗可以通过促进脂肪酸产生进一步扰乱肿瘤的能量代谢。在本文中，我们批判性地讨论脂肪酸代谢网络以及它如何特别在放射治疗的情况下调节免疫反应。版权©2023 Elsevier Inc. 版权所有。

Fatty acid metabolic reprogramming has emerged as a major regulator of anti-tumor immune responses with large body of evidence that demonstrate its ability to impact the differentiation and function of immune cells. Therefore, depending on the metabolic cues that stem in the tumor microenvironment, the tumor fatty acid metabolism can tilt the balance of inflammatory signals to either promote or impair anti-tumor immune responses. Oxidative stressors such as reactive oxygen species generated from radiation therapy can rewire the tumor energy supply, suggesting that radiation therapy can further perturb the energy metabolism of a tumor by promoting fatty acid production. In this review, we critically discuss the network of fatty acid metabolism and how it regulates immune response especially in the context of radiation therapy.Copyright © 2023 Elsevier Inc. All rights reserved.