巨噬细胞是先天免疫系统中的重要组成部分，参与健康生物过程以及疾病调节和治疗反应。电离辐射常用于癌症治疗，在较低剂量范围内作为炎症性疾病的添加治疗。一般来说，较低剂量的电离辐射被认为具有抗炎作用，而较高剂量则用于癌症治疗，在此剂量范围内会导致较明显的炎症反应，除了能控制肿瘤外。大多数对巨噬细胞进行体外实验的研究都证明了这一点，但是在体内，例如肿瘤相关巨噬细胞，则表现出矛盾的反应。尽管已经收集了一些文献关于辐射诱导的巨噬细胞调节方面的知识，但许多基本机制仍不清楚。然而，鉴于巨噬细胞在人体中的关键作用，它们是治疗的重要目标，可以潜在地有助于更好的治疗结果。因此，我们总结了巨噬细胞介导的辐射反应的当前知识。Copyright © 2023 Elsevier Inc.版权所有。

Macrophages are a vital part of the innate immune system that are involved in healthy biological processes but also in disease modulation and response to therapy. Ionizing radiation is commonly used in the treatment of cancer and, in a lower dose range, as additive therapy for inflammatory diseases. In general, lower doses of ionizing radiation are known to induce rather anti-inflammatory responses, while higher doses are utilized in cancer treatment where they result, next to tumor control, in rather inflammatory responses. Most experiments that have been carried out in ex vivo on macrophages find this to be true, however in vivo, tumor-associated macrophages, for example, show a contradictory response to the respective dose-range. While some knowledge in radiation-induced modulations of macrophages has been collected, many of the underlying mechanisms remain unclear. Due to their pivotal role in the human body, however, they are a great target in therapy and could potentially aid in better treatment outcome. We therefore summarized the current knowledge of macrophage mediated radiation responses.Copyright © 2023 Elsevier Inc. All rights reserved.