手术切除是治疗脑转移瘤常用的方法。脑转移瘤的位置可能会显著影响患者的生存率，因此在临床决策和患者咨询中可能需要考虑位置因素。本研究分析了基底和幕上脑转移瘤位置对预后的潜在影响。2013年至2019年，本文作者的神经肿瘤中心共接受245名单发脑转移瘤患者的脑转移瘤切除手术。为了在已知常见预后变量（肿瘤类型、年龄、手术前Karnofsky Performance评分和手术前Charlson并发症指数）之间生成协变量平衡，使用R进行了1:1比例的基底和幕上患者队列的倾向评分匹配。评估了两组单发脑转移瘤患者的总生存率（OS）。245名单发脑转移瘤患者中有61人（25%）患有基底脑转移瘤；184名患者（75%）患有幕上单发脑转移瘤。基底脑转移瘤患者的中位OS为11个月（95%置信区间（CI）为7.4-14.6个月）。与此相比，匹配的61名单发幕上脑转移瘤患者的中位OS为13个月（95% CI为10.9-15.1个月）（p=0.32）。本研究表明，在单发脑转移瘤患者接受手术治疗时，基底和幕上脑转移瘤的预后价值没有显著差异。这些结果可能可以鼓励医生在治疗 supra- and infratentorial 脑转移瘤时采用类似的手术治疗策略。©2023. 作者（们）。

Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore might be considered in clinical decision making and patient counseling. In the present study, the authors analyzed infra- and supratentorial BM location for a potential prognostic difference. Between 2013 and 2019, 245 patients with solitary BM received BM resection at the authors' neuro-oncological center. In order to produce a covariate balance for commonly-known prognostic variables (tumor entity, age, preoperative Karnofsky Performance Score, and preoperative Charlson Comorbidity Index), a propensity score matching at a ratio of 1:1 between the cohort of patients with infra- and supratentorial BM location was performed using R. Overall survival (OS) rates were assessed for both matched cohorts of patients with BM. Sixty-one of 245 patients (25%) with solitary BM exhibited an infratentorial tumor location; 184 patients (75%) suffered from supratentorial solitary BM. Patients with infratentorial BM revealed a median OS of 11 months (95% confidence interval (CI) 7.4-14.6 months). Compared with this, median OS for the group of 61 individually matched patients with solitary supratentorial solitary BM was 13 months (95% CI 10.9-15.1 months) (p = 0.32). The present study suggests that the prognostic value of infra- and supratentorial BMs does not significantly differ in patients that undergo surgery for solitary BM. These results might encourage physicians to induce surgical therapy of supra- and infratentorial BM in a similar manner.© 2023. The Author(s).