化学趋化因子属于细胞因子家族，具有趋化特性，能调节趋化和白细胞迁移，以及诱导血管生成和维持止血机制。姜黄素是姜黄根茎的主要成分，具有多种药理作用，包括抗炎、免疫调节、抗氧化和调节脂质的特性。姜黄素影响/调节化学趋化因子和化学趋化因子受体。因此，本综述重点关注姜黄素对趋化因子的作用的分子机制，并将众多报告姜黄素介导的对身体器官/系统（例如中枢神经系统、肝脏和心血管系统）的炎症情况实行调节的研究放入背景中进行评估。本文还回顾了姜黄素对病毒和细菌感染、癌症和不良妊娠结局的影响。© 2023作者（作者）独家许可Springer Nature Switzerland AG。

Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.