神经支配是癌症的更新标志之一，并且心理压力促进癌症的发生和进展，这已经得到了很好的确认。乳腺肿瘤的环境不仅包括成纤维细胞、脂肪细胞、内皮细胞和淋巴细胞，还包括越来越被发现在乳腺癌进展中起重要作用的神经元。周围神经，特别是交感、副交感和感觉神经，已被报道在乳腺癌中扮演重要但不同的角色。然而，它们在乳腺癌进展和治疗中的作用仍然存在争议。此外，大脑是乳腺癌转移的最爱部位之一。在本文中，我们首先总结了乳腺癌的神经支配及其在调节癌细胞生长和转移中的机制。接下来，我们总结了乳腺癌诊断和治疗中与神经相关的分子标记。此外，我们还回顾了用于阻断神经元与乳腺癌之间相互作用的药物和新兴技术。最后，我们讨论了这个领域未来的研究方向。总之，进一步研究乳腺癌及其与神经元或神经递质的相互作用，对乳腺癌的临床管理是很有前途的。©2023.作者。

It is well established that innervation is one of the updated hallmarks of cancer and that psychological stress promotes the initiation and progression of cancer. The breast tumor environment includes not only fibroblasts, adipocytes, endothelial cells, and lymphocytes but also neurons, which is increasingly discovered important in breast cancer progression. Peripheral nerves, especially sympathetic, parasympathetic, and sensory nerves, have been reported to play important but different roles in breast cancer. However, their roles in the breast cancer progression and treatment are still controversial. In addition, the brain is one of the favorite sites of breast cancer metastasis. In this review, we first summarize the innervation of breast cancer and its mechanism in regulating cancer growth and metastasis. Next, we summarize the neural-related molecular markers in breast cancer diagnosis and treatment. In addition, we review drugs and emerging technologies used to block the interactions between nerves and breast cancer. Finally, we discuss future research directions in this field. In conclusion, the further research in breast cancer and its interactions with innervated neurons or neurotransmitters is promising in the clinical management of breast cancer.© 2023. The Author(s).