HOX转录抗义间隔RNA（HOTAIR）是一种致癌非编码RNA，其表达与包括乳腺癌（BC）在内的多种癌症的肿瘤等级和预后密切相关。HOTAIR通过海绵和表观遗传机制调节各种靶基因，并控制各种致癌细胞和信号机制，包括转移和耐药性。在BC细胞中，HOTAIR表达受到多种转录和表观遗传机制的调节。在本文中，我们描述了在癌症发展过程中调节HOTAIR表达的机制，并探讨了HOTAIR如何驱动BC的发展、转移和耐药性。在本文的最后一部分中，我们着重讨论了HOTAIR在BC治疗管理、治疗和预后中的作用，突出了它的潜在治疗应用。©2023。作者。

HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.© 2023. The Author(s).