免疫疗法已成为许多癌症的有效治疗方式。它有一套独特的免疫系统相关不良反应，被称为免疫相关不良事件（irAEs）。皮肤毒性是最常见的irAEs，其中水疱性类天疱疮虽然罕见，但可能危及生命并影响患者的生存。在本文中，我们报道了一个pMMR /微卫星稳定（MSS）结直肠癌患者，其PD-1引起了水疱性类天疱疮的治疗。在甲基泼尼松龙每天两次缩减至4毫克后，在患者身上没有观察到明显的不良反应。患者近期没有出现新的皮肤损伤，原有的皮肤损伤得到了治愈。特别是，患者的免疫疗法没有停止，最佳结果是疾病的部分缓解，持续了8个多月。版权所有©2023 Wang、Shao、Xiao和Liu。

Immunotherapy has become a very effective treatment for many cancers. It has a unique set of immune system-related adverse effects, collectively known as immune-related adverse events (irAEs). Skin toxicities are the most common irAEs, of which bullous pemphigoid, although rare, is potentially life-threatening and affects patients' survival. In this article, we report the treatment of bullous pemphigoid caused by programmed cell death protein-1 (PD-1) in a case of proficient mismatch repair (pMMR)/microsatellite stable (MSS) colorectal cancer. No significant adverse effects were observed in the patient after methylprednisone was tapered to 4 mg twice a day. No new skin lesions occurred recently in the patient and the original skin lesions healed. In particular, the patient's immunotherapy was not stopped and the best outcome was a partial remission of the disease, lasting for more than 8 months.Copyright © 2023 Wang, Shao, Xiao and Liu.