脂肪干细胞（ASCs）在许多临床前研究中已被证明具有强大的免疫抑制作用。以前的研究表明，ASCs可能促进癌症进展和伤口愈合。然而，对原生或脂肪移植的脂肪组织对癌症复发的影响进行的临床研究结果各不相同。我们研究了口腔鳞状细胞癌（OSCC）重建游离皮瓣中的脂肪含量是否与疾病复发和/或创口并发症的减少有关。回顾性病历审查。学术医疗中心。我们对一个14个月内接受OSCC自由皮瓣重建手术的55名病人进行了审查。使用纹理分析软件，我们测量了术后计算机断层扫描中的相对自由皮瓣脂肪体积（FFFV），并将脂肪体积与患者的生存率、复发率和创口愈合并发症进行比较。我们报道了没有复发与存在复发的患者之间的平均FFFV无差异：癌症幸存者为13.47 cm3，而复发病例为17.99 cm3（p = .56）。FFV高低不影响2年无复发生存率，分别为61.0％和59.1％（p = .917）。虽然只有9名患者出现了创口愈合并发症，但我们发现高FFFV与低FFFV患者之间不存在创口愈合并发症的趋势。这表明FFFV与OSCC自由皮瓣重建手术患者的复发和创口愈合无关，因此重建外科医生无需担心脂肪含量问题。©2023作者。由Wiley Periodicals LLC代表美国听力和头颈外科基金会出版的OTO开放获取。

Adipose stem cells (ASCs) have been shown in many preclinical studies to be potent suppressors of the immune system. Prior studies suggest that ASCs may promote cancer progression and wound healing. However, clinical studies investigating the effects of native, or fat-grafted adipose tissue on cancer recurrence have generated mixed results. We investigated whether adipose content in reconstructive free flaps for oral squamous cell carcinoma (OSCC) is associated with disease recurrence and/or reduction in wound complications.Retrospective chart review.Academic medical center.We performed a review of 55 patients undergoing free flap reconstruction for OSCC over a 14-month period. Using texture analysis software, we measured the relative free flap fat volume (FFFV) in postoperative computed tomography scans and compared fat volume with patient survival, recurrence, and wound healing complications.We report no difference in mean FFFV between patients with or without recurrence: 13.47 cm3 in cancer-free survivors and 17.99 cm3 in cases that recurred (p = .56). Two-year recurrence-free survival in patients with high and low FFFV was 61.0% and 59.1%, respectively (p = .917). Although only 9 patients had wound healing complications, we found no trend in the incidence of wound healing complications between patients with high versus low FFFV.FFFV is not associated with recurrence or wound healing in patients undergoing free flap reconstruction for OSCC, suggesting adipose content should not be of concern to the reconstructive surgeon.© 2023 The Authors. OTO Open published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology–Head and Neck Surgery Foundation.