背景：人类染色体12中含有I kappa B激酶相互作用蛋白（IKBIP），也常被称为IKIP。IKBIP在肿瘤生长中的作用只在少数出版物中被讨论。 目的：探讨IKBIP在各种肿瘤发展以及肿瘤免疫微环境中的作用。 方法：使用UALCAN、HPA、基因型组织表达、癌症基因组地图和其他数据集来分析IKBIP表达。我们深入研究了IKBIP在泛癌症、临床特征和遗传异常中的预测重要性。研究是否存在IKBIP和免疫相关基因、微卫星不稳定性（MSI）以及肿瘤突变负荷（TMB）发生率之间的链接。使用ImmuCellAI、TIMER2和早期研究的免疫细胞浸润数据考察免疫细胞浸润和IKBIP表达之间的关系。最后，进行基因集富集分析（GSEA）以确定与IKBIP相关的信号通路。 结果：IKBIP在大多数癌症中高表达，并且与数种主要癌症类型的预后呈负相关。此外，IKBIP表达与13种癌症的TMB和7种癌症的MSI有关联。另外，IKBIP与众多免疫和促癌通路相关。同时，各种癌症类型具有独特的肿瘤浸润免疫细胞谱系。 结论：IKBIP具有作为泛癌症癌基因的潜力，对肿瘤发生和免疫都至关重要。提高的IKBIP表达意味着免疫抑制环境，并且可以用作预后生物标志物和治疗靶点。 版权所有©2023 Bi，Wang，Xiao，Zhao，Guo，Xiong，Ji，Li，Li和Qin。

Background: Human chromosome 12 contains I kappa B kinase interacting protein (IKBIP) is also commonly known as IKIP. The involvement of IKBIP in the growth of tumors has only been discussed in a small number of publications. Purpose: To explore the role that IKBIP plays in the development of a wide variety of neoplasms, as well as the tumor immunological microenvironment. Methods: UALCAN, HPA, Genotype Tissue Expression, Cancer Genome Maps, and other datasets were used to analyze IKBIP expression. We thoroughly investigated the predictive importance of IKBIP in pan-cancer, clinical traits, and genetic anomalies. We studied whether there is a link between IKBIP and immune-related genes, microsatellite instability (MSI), and the incidence of tumor mutational burden (TMB). The link between immune cell infiltration and IKBIP expression was examined using data on immune cell infiltration from ImmuCellAI, TIMER2, and earlier studies. Finally, gene set enrichment analysis (GSEA) was performed to determine the signaling pathways associated with IKBIP. Results: IKBIP is highly expressed in most cancers and is negatively associated with the prognosis of several major cancer types. Furthermore, IKBIP expression was linked to TMB in 13 cancers and MSI in seven cancers. Additionally, IKBIP is associated with numerous immunological and cancer-promoting pathways. Simultaneously, various cancer types have unique tumor-infiltrating immune cell profiles. Conclusion: IKBIP has the potential to act as a pan-cancer oncogene and is crucial for both carcinogenesis and cancer immunity. Elevated IKBIP expression implies an immunosuppressive environment and may be used as a prognostic biomarker and therapeutic target.Copyright © 2023 Bi, Wang, Xiao, Zhao, Guo, Xiong, Ji, Li, Li and Qin.